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Ageing faster and more knee pain are associated with low vitamin D – March 2022


Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals

The journal of nutrition, health & aging (2022) https://doi.org/10.1007/s12603-022-1758-z
L. J. Strath, L. Meng, A. Rani, P. Sinha, A. J. Johnson, Z. Huo, T. C. Foster, J. D. Edburg, R. B. Fillingim & Yenisel Cruz-Almeida

Image
Objectives
To examine the relationship between Vitamin D status and pain intensity and disability in individuals with and without knee pain, and to examine the role of epigenetics in this relationship.

Design
Cross-sectional analysis of data from the UPLOAD-2 study (Understanding Pain and Limitations in OsteoArthritic Disease-2).

Participants
189 individuals aged 45–65 years and older.

Measurements
Serum Vitamin D levels, pain related interference and characteristic pain intensity measures, and the epigenetic clock GrimAge derived from blood analyses.

Results
Lower Vitamin D was associated with advanced epigenetic aging (AgeAccelGrim), greater pain and disability and that (AgeAccelGrim) mediated the relationship between Vitamin D status and self-reported pain (ab = -0.0799; CI [-0.1492, -0.0237]) and disability (ab = -0.0669; CI [-0.1365, -0.0149]) outcomes.

Conclusion
These data support the notion that lifestyle factors such as nutrition status play a key role in aging process, as well as the development and maintenance of age-related diseases such as pain. Modifying nutrition status could help promote healthy aging and reduce pain.
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VitaminDWiki - Osteoarthritis pages with KNEE in title (29 as of March 2022)

This list is automatically updated

Items found: 31
Title Modified
Total knee arthroplasty – worse outcome if low vitamin D – many studies 05 Apr, 2024
Knee osteoarthritis treated by Vitamin D - many studies 13 Dec, 2023
Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis Aug 2023 21 Aug, 2023
Ageing faster and more knee pain are associated with low vitamin D – March 2022 08 Mar, 2022
I needed more than Vitamin D to treat my knee osteoarthritis 06 Nov, 2021
Knee osteoarthritis helped by Low Level Laser Therapy 02 Nov, 2020
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 21 Oct, 2020
Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 10 Oct, 2018
Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 10 Jul, 2018
If You Tear a Knee Ligament, Arthritis Is Likely to Follow in 10 Years (both are related to low Vitamin D) – Nov 2017 08 Nov, 2017
More pain after knee surgery if low vitamin D – Oct 2015 26 Aug, 2017
Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 29 Jul, 2017
Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 29 Jul, 2017
Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 29 Jul, 2017
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 20 Jul, 2017
Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 25 Apr, 2017
Knee osteoarthritis strongly associated with low Boron – 2015 24 Mar, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 24 Dec, 2016
Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 21 Dec, 2016
Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 22 Nov, 2016
Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 06 Oct, 2016
Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 06 Oct, 2016
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 08 Mar, 2016
Knee pain in seniors predicted by low vitamin D 5 years before – Feb 2014 27 Oct, 2015
Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 03 Oct, 2015
Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT 08 Aug, 2015
Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 12 Apr, 2015
Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 23 Feb, 2015
Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 07 Oct, 2014
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 10 Nov, 2012
Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 10 Nov, 2012

VitaminDWiki pages with EPIGENETICS in title

This list is automatically updated

Items found: 19
Title Modified
Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024 26 Mar, 2024
Epigenetics and Vitamin D – many studies 23 Oct, 2023
Vitamin D Health problems can run in families (epigenetics, they miss other reasons) – June 2023) 16 Jun, 2023
Vitamin D supplementation is associated with slower epigenetic aging - May 2022 21 Jun, 2022
Epigenetics, vitamin D, and Multiple Sclerosis 15 Jun, 2022
Epigenetics - PDFs and links, with and without Vitamin D 25 Feb, 2021
Epigenetics identified Cervical Cancer 100 percent of time – 2019 23 Dec, 2019
Stressors as a fetus or child can cause health problems in adult (perhaps via epigenetics) – Dec 2017 14 Oct, 2018
Health problems can persist through many generations – Epigenetics and Vitamin D 13 Oct, 2018
Epigenetics meets endocrinology – 2011 13 Oct, 2018
Vitamin D Receptor – environment, genetics and epigenetics – May 2015 13 Oct, 2018
Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016 05 May, 2016
Epigenetics of Multiple Sclerosis – March 2014 06 Sep, 2015
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015
Epigenetics meets endocrinology - 2011 21 Jan, 2015
Hypothesis: Epigenetics, vitamin D, and Multiple Sclerosis – Nov 2012 29 Aug, 2014
Epigenetics of prostate cancer and vitamin D – June 2010 09 Jul, 2013
Lung disease, vitamin D, and epigenetics – Aug 2011 13 Feb, 2012
Epigenetics and vitamin D – June 2010 clips from the web 05 Jun, 2010

VitaminDWiki pages - Meta-analysis and Pain


Created by admin. Last Modification: Tuesday March 8, 2022 13:13:41 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
17170 GRIMAGE April 2021.pdf admin 08 Mar, 2022 518.40 Kb 325
17169 knee pain age.jpg admin 08 Mar, 2022 49.78 Kb 230
17168 Strath2022_Article_AcceleratedEpigeneticAgingMedi.pdf admin 08 Mar, 2022 405.01 Kb 219