Reduced: Autism, ADHD, Depression. etc
Notes:
- 1) Finland was supplementing milk with Vitamin D during the study, so both groups got more D
- 2) Study might have found better benefit if it had increased vitamin D dose with increased body weight
- Infant body weight triples in 24 months - so probably need 3600 IU at 24 months
- 3) Study might have found better benefit if it had adjusted vitamin D dose with BMI
- Obese needs >2X more vitamin D
- 4) Study might have found better benefits if supplementation had started before birth
- 5) Study might have found better benefits with non-daily supplementation
- 6) Study found a 79% reduction in problems if 1200 IU when mothers had Vitamin D levels <30 ng
- 7) Preemies need even more vitamin D – no comment in study about preemies
- Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years: A Randomized Clinical Trial
- Study was reviewed at TrialSiteNews
- VitaminDWiki -
19 studies in both categories Infant-Child and Autism - VitaminDWiki -
15 studies in both categories Infant-Child and ADHD - VitaminDWiki -
5 studies in both categories Infant-Child and Depression - VitaminDWiki -
11 studies in both categories Intervention and Autism - VitaminDWiki -
5 studies in both categories Intervention and ADHD - VitaminDWiki – Infant-Child category has
844 items and contains
Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years: A Randomized Clinical Trial
JAMA Netw Open. 2023 May 1;6(5):e2314319. doi: 10.1001/jamanetworkopen.2023.14319.
Samuel Sandboge 1 2, Katri Räikkönen 3, Marius Lahti-Pulkkinen 2 3 4, Helena Hauta-Alus 2 5 6 7, Elisa Holmlund-Suila 5 7, Polina Girchenko 3, Eero Kajantie 2 5 6 8, Outi Mäkitie 5 7 9 10 11, Sture Andersson 5, Kati Heinonen 1 3 12Importance: Vitamin D is associated with neurodevelopment, but causality, critical windows, and potentials for modification remain unknown.
Objective: To determine the impact of high-dose (1200 IU) vs standard-dose (400 IU) vitamin D3 supplementation during the first 2 years on psychiatric symptoms at ages 6 to 8 years and whether the impact is different in children with lower vs higher maternal vitamin D3 levels; lower vs higher levels were defined as 25-hydroxyvitamin D (25[OH]D) less than 30 ng/mL vs 30 ng/mL or greater.
Design, setting, and participants: This study was a long-term follow-up of the double-blind randomized clinical trial (RCT) Vitamin D Intervention in Infants (VIDI) conducted at a single center in Helsinki, Finland, at 60 degrees north latitude. Recruitment for VIDI took place in 2013 to 2014. Follow-up data for secondary data analysis were collected 2020 to 2021. VIDI originally included 987 term-born infants; 546 of these individuals participated in the follow-up at ages 6 to 8 years, among whom 346 individuals had data on parent-reported psychiatric symptoms. Data were analyzed from June 2022 to March 2023.
Interventions: There were 169 infants randomized to receive 400-IU and 177 infants randomized to receive 1200-IU oral vitamin D3 supplementation daily from ages 2 weeks to 24 months.
Main outcomes and measures: Primary outcomes were internalizing, externalizing, and total problems scores, with clinically significant problems defined as T scores of 64 or greater in the Child Behavior Checklist questionnaire.
Results: Among 346 participants (164 females [47.4%]; mean [SD] age, 7.1 [0.4] years), the vitamin D3 dose was 400 IU for 169 participants and 1200 IU for 177 participants.
Clinically significant internalizing problems occurred in- 0 participants in the 1200-IU group (5.6% prevalence) compared with
- 20 participants (11.8%) in the 400-IU group (odds ratio, 0.40; 95% CI, 0.17-0.94; P = .04)
after adjustment for sex, birth season, maternal depressive symptoms at birth, and parental single status at follow-up.
In a post hoc subgroup analysis, 48 children in the 400-IU group with maternal 25(OH)D concentrations less than 30 ng/mL had higher internalizing problems scores compared with children in the 1200-IU group, including 44 children with maternal 25(OH)D concentrations below 30 ng/mL (adjusted mean difference, 0.49; 95% CI, 0.09-0.89; P = .02) and 91 children with maternal concentrations above 30 ng/mL (adjusted mean difference, 0.37; 95% CI, 0.03-0.72; P = .04). Groups did not differ in externalizing or total problems.
Conclusions and relevance: This randomized clinical trial found that higher-than-standard vitamin D3 supplementation in the first 2 years decreased risk of internalizing problems at ages 6 to 8 years.
Download the PDF from VitaminDWiki
Study was reviewed at TrialSiteNews
VitaminDWiki -
19 studies in both categories Infant-Child and Autism This list is automatically updated
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- Transgender associated with autism, low vitamin D, low BMD, etc. - many studies
- Brain and Vitamin D - many studies
- Autism may be synergistically treated by Vitamin D and probiotics – July 2022
- Autism increased 53 percent between 2017 and 2020 - July 2022
- Lower IQ among Autistic Black children (5 in 10) than White (3 in 10) - Dec 2021
- Autism associated with low Vitamin D (again) – Meta-Analysis Jan 2021
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- Vaccinated children had more chronic diseases - Sept 2018
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Autistic children were 3.6 X more likely to have low levels of vitamin D – Nov 2017
- Autistic children have lower levels of Iron, Vitamin D, Magnesium, etc – Oct 2017
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
- Vitamin D (40-70 ng) in Children’s Health – review Sept 2014
- Childhood mental disorders vs levels of vitamin D – July 2013
VitaminDWiki -
15 studies in both categories Infant-Child and ADHD This list is automatically updated
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- ADHD significantly treated by daily Magnesium plus weekly Vitamin D – RCT April 2021
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- ADHD risk factors include low Zinc, Vitamin D, Magnesium and Omega-3 (umbrella review) – Oct 2020
- Behavior disorders reduced with Magnesium, Omega-3, and Zinc
- ADHD children eat less fatty fish (Omega-3 again) – May 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Attention Deficit Hyperactivity Disorder impulsivity reduced by daily 1,000 IU of vitamin D – RCT Jan 2019
- Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
- Vaccinated children had more chronic diseases - Sept 2018
- Omega-3 reduced violence in children and violence between parents – RCT May 2018
- ADHD in children 2.6 X more likely if low vitamin D – meta-analysis Feb 2018
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
- ADHD and Vitamin D Deficiency
VitaminDWiki -
5 studies in both categories Infant-Child and Depression This list is automatically updated
- Depressed infants have very low Vitamin D (7.5 ng) – June 2023
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- Mental health of children: vast majority of studies reviewed found that vitamin D helped – March 2021
- 2.5 X more health compaints in children and youths if low vitamin D – Jan 2021
- Children with allergies often depressed and anxious (low micro-nutrients, such as vitamin D, were not mentioned) – July 2019
VitaminDWiki -
11 studies in both categories Intervention and Autism This list is automatically updated
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Autistics have half of the response to Vitamin D – RCT Oct 2018
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
- Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
VitaminDWiki -
5 studies in both categories Intervention and ADHD This list is automatically updated
- Children with ADHD again helped by 50,000 IU weekly Vitamin D – RCT June 2024
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- ADHD 1.5X less likely if 4,400 IU Vitamin D daily during pregnancy - RCT Sept 2021
- Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
- ADHD reduced by just 3,000 IU of Vitamin D and methylphenidate for just 12 weeks – RCT Feb 2018
VitaminDWiki – Infant-Child category has
844 items and contains - No consensus on MINIMUM International Units (IU) for healthy infant of normal weight
- 400 IU Vitamin D is no longer enough
Was OK in the past century, but D levels have been dropping for a great many reasons.
FDA doubles the amount of vitamin D permitted in milk – July 2016 - No consensus: range is 600 to 1600 IU – based on many randomized controlled trials
- Review of 400 IU to 2000 IU daily and higher if non-daily
- Fewer pre-infants were vitamin D deficient when they got 800 IU – RCT Feb 2014
- 1600 IU was the conclusion of three JAMA studies
1000 IU recommended in France and Finland – 2013 - appears to be a good level - 5X less mite allergy after add vitamin D
- Child bone fractures with low vitamin D were 55X more likely to need surgery
- 75 % of SIDS had low vitamin D
- Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
- 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014
- Infants have gotten free 400 IU of vitamin D in Turkey since 2005, More for longer would be even better – Feb 2022
- Preemies should have vitamin D supplements – reaching an agreement – April 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
Having a good level of vitamin D cuts in half the amount of:
- Asthma, Chronic illness, Doctor visits, Allergies, infection
Respiratory Tract Infection, Growing pains, Bed wetting
Need even more IUs of vitamin D to get a good level if;
- Have little vitamin D: premie, twin, mother did not get much sun access
- Get little vitamin D: dark skin, little access to sun
- Vitamin D is consumed faster than normal due to sickness
- Older (need at least 100 IU/kilogram, far more if obese)
- Not get any vitamin D from formula (breast fed) or (fortified) milk
Note – formula does not even provide 400 IU of vitamin D daily
Infants-Children need Vitamin D
- Sun is great – well known for 1,000’s of years.
US govt (1934) even said infants should be out in the sun - One country recommended 2,000 IU daily for decades – with no known problems
- As with adults, infants and children can have loading doses and rarely need tests
- Daily dose appears to be best, but monthly seems OK
- Vitamin D is typically given to infants in the form of drops
big difference in taste between brands
can also use water-soluable form of vitamin D in milk, food, juice, - Infants have evolved to get a big boost of vitamin D immediately after birth
Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare - 100 IU per kg of infant July 2011, Poland etc.
More than 100 IU/kg is probably better 844 items in the category Infant/Child See also - 34 pages in VitaminDWiki had BREASTFE*in title as of Jan 2022
- "BIRTH DEFECTS" 172 items as of July 2016
- Stunting OR “low birth weight” OR LBW OR preemie OR preemies OR preterm 1940 items as of Oct 2018
- 96 VitaminDWiki pages contained PRETERM or PREEMIE in title as of Aug 2021
- "SUDDEN INFANT DEATH" OR SIDS 214 items as of Dec 2020
- Overview of Rickets and Vitamin D
- Youth category listing has
174 items along with related searches - Down's syndrome and low vitamin D - several studies
- Rett syndrome associated with low vitamin D, treated by Omega-3
Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023(Cached) Printer Friendly Follow this page for updates1510 visitors, last modified 29 May, 2023, This page is in the following categories (# of items in each category)
- VitaminDWiki -