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Fecal transplant from young reduced age-associated defects in old (mice so far) – Aug 2021

Microbiota from young mice counteracts selective age-associated behavioral deficits

Nature Aging volume 1, pages 666–676 (2021) https://doi.org/10.1038/s43587-021-00093-9 Publisher charges costs $9 for PDF
Marcus Boehme, Katherine E. Guzzetta, Thomaz F. S. Bastiaanssen, Marcel van de Wouw, Gerard M. Moloney, Andreu Gual-Grau, Simon Spichak, Loreto Olavarría-Ramírez, Patrick Fitzgerald, Enrique Morillas, Nathaniel L. Ritz, Minal Jaggar, Caitlin S. M. Cowan, Fiona Crispie, Francisco Donoso, Evelyn Halitzki, Marta C. Neto, Marzia Sichetti, Anna V. Golubeva, Rachel S. Fitzgerald, Marcus J. Claesson, Paul D. Cotter, Olivia F. O’Leary, Timothy G. Dinan & John F. Cryan

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Examples of relevent Human studies

  • Cognitive function improvement after fecal microbiota transplantation in Alzheimer's dementia patient: a case report - Aug 2021 FREE PDF
  • Effects of the Human Gut Microbiota on Cognitive Performance, Brain Structure and Function: A Narrative Review - Oct 2020 FREE PDF
  • The relationship between the gut microbiome and mild cognitive impairment in patients without dementia: a cross-sectional study conducted in Japan - FREE PDF
  • The Gut Microbiome as a Therapeutic Target for Cognitive Impairment Dec 2019 - FREE PDF

Vitamin D can improve the gut bacteria - no transplant required


The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3–4 months) or old (19–20 months) donor mice into aged recipient mice (19–20 months).
Transplant of a microbiota from young donors

  • reversed aging-associated differences in peripheral and brain immunity,
  • as well as the hippocampal metabolome and transcriptome of aging recipient mice.

Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.


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