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Multiple Sclerosis risk of relapse reduced by 13 percent for every 2.5 ng higher level of vitamin D (under age 37) – June 2017

Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up

. PLoS ONE 11(6): e0156122. doi:10.1371/ journal.pone.0156122

VitaminDWiki comment

The Vitamin D benefit was only noticed in those < age 37
Suspect a similar benefit would be noticed for those having MS for a short time (< 5 years)
Only rarely can a modest level of Vitamin D undo the long-term ravages of a disease

See also VitaminDWiki

Overview MS and vitamin D contains the following summary
Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.


Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description
Vitamin D Protocol used by Dr. Coimbra for Multiple Sclerosis etc.
Snips as of April 2016 http://www.vitamindprotocol.com/dr.-coimbra-s-ms-protocol.html

  • 1,000 IU's vitamin D per kilogram as a first approximation
    (apparently increased/decreased depending of resulting vitamin D blood level)
  • Vitamin B2, magnesium glycinate, boron, chromium picolinate, Omega 3 DHA, Zinc, Methylcobalamin form of B12, Choline, etc.
  • Lack of B12 may affect 10%–15% of the general population and may be the most prevalent genetic risk factor for several human diseases
  • Discontinue eating or drinking dairy products or calcium enriched foods or beverages, also no Ca supplements
  • Drink as least 2.5 liters [85 ounces] of fluids, preferably water
  • Required Tests:​ Vitamin D, Parathyroid, Blood calcium, urinary calcium


 Download the PDF from VitaminDWiki

Anne-Hilde Muris1,2*, Joost Smolders20, Linda Rolf1,2, Lieke J. J. Klinkenberg3,
Noreen van der Linden3, Steven Meex3, Jan Damoiseaux3, Raymond Hupperts1,2
1 School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands,
2 Academic MS Center Limburg, Zuyderland Medical Center, Sittard, the Netherlands,
3 Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands
a Current address: Department of Neurology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands * a.muris at maastrichtuniversity.nl

Background and Objective
The risk of developing multiple sclerosis (MS) as well as MS disease activity is associated with vitamin D (25(OH)D) status. The relationship between the main functional disability hallmark of MS, disability progression, and 25(OH)D status is less well established though, especially not in MS patients with progressive disease.

Methods
This retrospective follow-up study included 554 MS patients with a serum baseline 25(OH) D level and Expanded Disability Status Scale (EDSS) with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25(OH)D status on relapse rate. Repeated measures linear regression analyses were performed to assess the effect on disability and disability progression.

Results
Baseline deseasonalized 25(OH)D status was associated with subsequent relapse risk (yes/no), but only in the younger MS patients (< 37.5 years; OR = 0.872, per 10 nmol/L 25 (OH)D, p = 0.041). Baseline 25(OH)D status was not significantly associated with either disability or disability progression, irrespective of MS phenotype.

Conclusion
Within the physiological range, 25(OH)D status is just significantly associated with the occurrence of relapses in younger MS patients, but is not associated with disability or disability progression over three years follow-up. Whether high dose supplementation to supra physiological 25(OH)D levels prevents disability progression in MS should become clear


Created by admin. Last Modification: Tuesday July 18, 2017 21:07:02 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
8197 MS RR.pdf PDF 2017 admin 18 Jul, 2017 20:58 781.72 Kb 503
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