Eur Respir J. 2011 May 12.
Hollams EM, Hart PH, Holt BJ, Serralha M, Parsons F, de Klerk NH, Zhang G, Sly PD, Holt PG.
and Centre for Child Health Research, The University of Western Australia Perth Australia.
Vitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children with established disease, but its role in disease inception at community level is less clear. To investigate associations between vitamin D status and biological signatures indicative of allergy and asthma development in children aged 6 and 14 years in Perth, Western Australia (32°S). Serum vitamin D was assayed in 989 6-year-olds and 1380 14-year-olds from an unselected community birth cohort; 689 were assessed at both ages. Vitamin D levels were assessed as a risk modifier for respiratory and allergic outcomes at both ages, utilising previously ascertained phenotypic data.
The predictive value of vitamin D levels at age 6 for development of clinical phenotypes at age 14 was also examined.
Serum vitamin D levels in children at both ages were negatively associated with concurrent allergic phenotypes; gender stratification revealed that this association was restricted mainly to boys.
Further, vitamin D levels at age 6 were significant predictors of subsequent atopy/asthma-associated phenotypes at age 14.
In a non-selected community setting, children (particularly boys) with inadequate vitamin D are at increased risk of developing atopy, and subsequently bronchial hyperresponsiveness and asthma. In a large unselected cohort, males with inadequate vitamin D at 14 and 6 years had increased atopy and bronchial hyperresponsiveness. Low vitamin D at age 6 was a predictor of atopy and asthma at 14.
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