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Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses) – Oct 2017

Nutrients 2017, 9(10), 1120; doi:10.3390/nu9101120, 13 October 2017
Alfredo Garcia Layana 1,* , Angelo Maria Minnella 2OrcID, Gerhard Garhöfer 3, Tariq Aslam 4,5OrcID, Frank G. Holz 6, Anita Leys 7, Rufino Silva 8,9,10,11OrcID, Cécile Delcourt 12, Eric Souied 13 and Johanna M. Seddon 14,15

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see also Myopia    Tears often have higher levels of vitamin D than does blood – Sept 2016

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In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.

Created by admin. Last Modification: Thursday January 18, 2018 11:23:41 UTC by admin. (Version 6)

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9212 AMD.pdf PDF 2017 admin 18 Jan, 2018 10:52 1.13 Mb 35
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