Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies
BMJ Open 2017;7:e016404 http://dx.doi.org/10.1136/bmjopen-2017-016404
Yao Chen1, Beibei Zhu1,2, Xiaoyan Wu1,2, Si Li3, Fangbiao Tao1,2
Small for gestational age birth was 6.5X more likely if mother was vitamin D deficient – March 2015
Preterm birth rate reduced by vitamin D – 78 percent if non-white, 39 percent if white – July 2017
Poor motor development in infant was 40 percent more likely if low maternal vitamin D – July 2017
50,000 IU of vitamin D for 8 weeks of pregnancy raised most above 30 nanograms - RCT Jan 2017
Low Vitamin D results in adverse pregnancy and birth outcomes – Wagner meta-analysis March 2017
Preterm birth rate reduced by 43 percent with adequate Vitamin D supplementation – meta-analysis Feb 2017
Higher birth weight resulted in more fit adults (Vitamin D not mentioned) – Jan 2020
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- Overview Pregnancy and vitamin D
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28 ; Depression 21 ; Diabetes 43 ; Obesity 15 ; Hypertension 43 ; Breathing 33 ; Omega-3 40 ; Vitamin D Receptor 24 Click here for details - All items in category Infant/Child
802 items - Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
- 38+ papers with Breastfed etc, in the title
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
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- "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
- 94+ Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 937 items in text as of Aug 2020
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132 items along with related searches - (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D summary:
ProblemReduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
Download the PDF from VitaminDWikiForest plot - summarixes the differences between the studies
Objective To determine whether maternal vitamin D deficiency during pregnancy is associated with small for gestational age (SGA).
Methods A comprehensive literature search of PubMed, the Cochrane Library, Embase, and the Elsevier ScienceDirect library was conducted to identify relevant articles reporting prospective cohort studies in English, with the last report included published in February 2017. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to evaluate the correlation in a random effects model.
Results A total of 13 cohort studies were included in this meta-analysis with a sample of 28 285 individuals from seven countries. The pooled overall OR for babies born SGA was 1.588 (95% CI 1.138 to 2.216; p<0.01) for women with vitamin D deficiency. The prevalence of vitamin D deficiency during pregnancy varied from 13.2% to 77.3%. Subgroup analyses identified no significant differences in the association between vitamin D deficiency and SGA based on study quality, gestational week during which blood sampling was performed, cut-off vitamin D levels, sample size, adjustment for critical confounders and method for measuring vitamin D.
Conclusion This meta-analysis suggests that vitamin D deficiency is associated with an increased risk of SGA.
Small for gestational age is 1.6 X more likely if mother was vitamin D deficient – meta-analysis Aug 2017(Cached) Printer Friendly Follow this page for updates5864 visitors, last modified 04 Feb, 2020, This page is in the following categories (# of items in each category)Attached files
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