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Fatigue reduced by Vitamin D (Cancer, muscle, MS, age, etc) - many studies


Highlighed studies in VitaminDWiki

Cancer

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Did not even mention Vitamin D - Nov 2023
How can we improve our approach to cancer-related fatigue? MD Edge

  • "Cancer-related fatigue is said to affect
    • 40% of patients at the time of cancer diagnosis,
    • 65% of patients during active or maintenance treatment,
    • 21%-52% of patients in the 5 years following cancer diagnosis, and even
    • one quarter of patients who are between 5 and 30 years post diagnosis,"
  • cancer-related fatigue is “a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning.”

90% of advanced Cancer patients have fatigue and low level of Vitamin D - 2015

Vitamin D deficiency and its association with fatigue and quality of life in advanced cancer patients under palliative care: A cross-sectional study
Palliative Medicine Volume 30, Issue 1 https://doi.org/10.1177/0269216315601954
Montserrat Martínez-Alonso montserrat.martinez at cmb.udl.cat, Adriana Dusso,

Background:
A normal vitamin D status is required for bones and muscles to maintain their function and structure, but it also contributes to the functional integrity of other multiple physiologic systems in the body.

Aim: To assess the relationship of Vitamin D deficiency with health-related quality-of-life issues, fatigue, and physical functioning in advanced cancer patients.

Design: This is a cross-sectional study.

Patients/settings: Adults under palliative care, having a locally advanced or metastatic or inoperable solid cancer.

Results:
Among 30 patients in palliative care with advanced solid cancer, 90% were vitamin D deficient. Serum Vitamin D concentration was positively correlated with patient-reported absence of fatigue (s = 0.49), and physical and functional well-being (s = 0.44 and s = 0.41, respectively, p < 0.01). Fatigue was the symptom with the highest median impact on their lives and was the only one associated with serum vitamin D (p = 0.031), with lower fatigue in patients with vitamin D concentrations in the third tertile. There was no evidence of a direct association between health-related quality of life and vitamin D status.

Conclusion:
The 90% frequency of advanced cancer patients with vitamin D deficiency, together with the positive correlation of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient’s quality of life.
 Download the PDF from Sci-Hub via VitaminDWiki


Less fatigue in Colorectal Cancer Survivors who had higher Vitamin D levels - 2020

Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment
Cancer Epidemiol Biomarkers Prev (2020) 29 (6): 1135–1144. https://doi.org/10.1158/1055-9965.EPI-19-1522
Janna L. Koole ; Martijn J.L. Bours; Eline H. van Roekel; José J.L. Breedveld-Peters; Fränzel J.B. van Duijnhoven ; Jody van den Ouweland; Stéphanie O. Breukink; Maryska L.G. Janssen-Heijnen; Eric T.P. Keulen ; Matty P. Weijenberg

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Background:
Vitamin D status may be an important determinant of health-related quality of life of colorectal cancer survivors. The current study investigated longitudinal associations between serum 25-hydroxyvitamin D3 (25OHD3) concentrations and quality of life in stage I–III colorectal cancer survivors up to 2 years after treatment.

Methods:
Patients with colorectal cancer (n = 261) were included upon diagnosis. Home visits (including blood sampling) were performed at diagnosis and at 6 weeks, 6 months, 1 year, and 2 years after treatment. Serum 25OHD3 concentrations were measured using LC/MS-MS and adjusted for season. Validated questionnaires were used to assess global quality of life and cognitive functioning (EORTC-QLQ-C30), fatigue (EORTC-QLQ-C30 and Checklist Individual Strength, CIS), and depression and anxiety (Hospital Anxiety and Depression Scale). Statistical analyses were performed using linear mixed models and adjusted for sex, age, time since diagnosis, therapy, comorbidities, physical activity, and body mass index.

Results:
At diagnosis, 45% of patients were vitamin D deficient (<50 nmol/L). After treatment, 25OHD3 concentrations increased on average with 3.1 nmol/L every 6 months. In confounder-adjusted models, 20 nmol/L increments in 25OHD3 were longitudinally associated with increased global quality of life [β 2.9; 95% confidence interval (CI), 1.5–4.3] and reduced fatigue (EORTC-QLQ-C30 subscale: β −3.5; 95% CI, −5.3 to −1.8 and CIS: β −2.8; 95% CI, −4.7 to −0.9). Observed associations were present both within and between individuals over time.

Conclusions:
Higher concentrations of 25OHD3 were longitudinally associated with better global quality of life and less fatigue in colorectal cancer survivors.

Impact:
This study suggests that higher 25OHD3 concentrations may be beneficial for colorectal cancer survivors. Future intervention studies are needed to corroborate these findings.
 Download the PDF from VitaminDWiki


Decrease in Serum Vitamin D Level of Older Patients with Fatigue - Oct 2019

Nutrients Volume 11 Issue 10 10.3390/nu11102531
by Manuela Pennisi 1,Giulia Malaguarnera 1,2ORCID,Giuseppe Di Bartolo 2,Giuseppe Lanza 3,4ORCID,Rita Bella 5ORCID,Eleonora Margherita Chisari 6,Omar Cauli 7ORCID,Enzo Vicari 8 andMichele Malaguarnera 2,7,*ORCID

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Fatigue is characterized by reduced energy level, decreased muscle strength, and a variable degree of cognitive impairment. Recent evidences seem to link vitamin D deficiency to fatigue. The aim of this study was to assess and compare vitamin D status in a cohort of older subjects with and without fatigue. We recruited a total of 480 subjects, 240 patients with fatigue and 240 controls without fatigue, from the Cannizzaro Hospital of Catania (Italy). Fatigue severity was measured by the fatigue severity scale, whereas mental and physical fatigue were measured through the Wessely and Powell fatigue scale, respectively. We also measured several blood parameters and 25-OH vitamin D. Subjects with fatigue showed lower levels of vitamin D as compared with those without fatigue. Blood levels of parameters related to fatigue were normal in both groups of subjects, however, platelet, hemoglobin, hematocrit (p < 0.05), mean corpuscular volume, C-reactive protein (CRP), iron, vitamin B12, and folic acid (p < 0.001) were significantly higher in the fatigue group with respect to the control group. Moreover, compared to controls, patients showed higher scores in the physical (p < 0.001), mental (p < 0.001), and severity (p < 0.001) fatigue scales. Finally, vitamin D inversely correlated with fatigue severity (r = −0.428, p < 0.01), whereas creatine kinase and CRP levels did not correlate with vitamin D. In conclusion, our data showed a direct link between vitamin D and fatigue in older subjects, suggesting translational implications in the diagnosis and management of these patients.
 Download the PDF from VitaminDWiki


Fatigue decreased somewhat after a single 100,000 IU dose of Vitamin D - RCT Dec 2016

__Effect of vitamin D3 on self-perceived fatigue - A double-blind randomized placebo-controlled trial
Medicine (Baltimore). 2016 Dec; 95(52): e5353. doi: 10.1097/MD.0000000000005353__
Albina Nowak, MD,a,∗ Lukas Boesch, MD,a Erik Andres, MD,a Edouard Battegay, PhD,a Thorsten Hornemann, PhD,b Christoph Schmid, PhD,c Heike A. Bischoff-Ferrari, PhD,d Paolo M. Suter, PhD,a and Pierre-Alexandre Krayenbuehl, MDa,e

Background: Vitamin D deficiency is frequent and has been associated with fatigue in uncontrolled trials.

Methods:
This is the first double-blind placebo-controlled clinical trial to investigate the efficacy of per os vitamin D3 (cholecalciferol) in treating fatigue among otherwise healthy persons with low serum 25-hydroxyvitamin D (25(OH)D) levels. We enrolled 120 individuals (mean age 29 ± 6 years, 53% women) presenting with fatigue and vitamin D deficiency (serum 25(OH)D < 20 μg/L). Participants were randomized to a single oral dose of 100,000 units of vitamin D or placebo. The primary endpoint was intra-individual change in the fatigue assessment scale (FAS) at 4 weeks after treatment.

Result:
The mean age of the participants was 29 ± 6 years, 53% were women. Mean FAS decreased significantly more in the vitamin D group (−3.3 ± 5.3; 95% confidence interval [CI] for change −14.1 to 4.1) compared with placebo (−0.8 ± 5.3; 95% CI for change −9.0 to 8.7); (P = 0.01). Amelioration of fatigue was reported more frequently in vitamin D than in placebo group (42 [72%] vs. 31 [50%]; P = 0.01; odds ratio [OR] 2.63, 95% CI for OR 1.23–5.62). Among all participants, improvement in fatigue score correlated with the rise in 25(OH)D level (R = −0.22, P = 0.02).

Conclusion:
Vitamin D treatment significantly improved fatigue in otherwise healthy persons with vitamin D deficiency.
 Download the PDF from VitaminDWiki


Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study)

N Am J Med Sci. 2014 Aug; 6(8): 396–402. doi: 10.4103/1947-2714.139291
Satyajeet Roy, Anthony Sherman, Mary Joan Monari-Sparks, Olga Schweiker, and Krystal Hunter1

Background:
Fatigue is a common presenting complaint of patients in the primary care offices. Low levels of vitamin D have been associated with fatigue in cancer patients. Normalization of vitamin D level improves their fatigue. Whether low vitamin D plays a role in fatigue in medically stable patients is not known.

Aims:
This prospective non-randomized therapeutic study observed the prevalence of low vitamin D in fatigue and the effect of normalization of vitamin D on fatigue.

Material and Methods:
One hundred and seventy four adult patients, who presented in our primary care office with fatigue and stable chronic medical conditions,completed fatigue assessment questionnaires. Patients with low vitamin D levels received ergocalciferol therapy for 5 weeks. Scores of pre- and post-treatment fatigue assessment questionnaires were compared.

Results:
Prevalence of low vitamin D was 77.2% in patients who presented with fatigue. After normalization of vitamin D levels fatigue symptom scores improved significantly (P < 0.001) in all five subscale categories of fatigue assessment questionnaires.

Conclusion:
The prevalence of low vitamin D is high in patients who present with fatigue and stable chronic medical conditions, if any. Normalization of vitamin D levels with ergocalciferol therapy significantly improves the severity of their fatigue symptoms.
 Download the PDF from VitaminDWiki


A meer 4,000 IU Vitamin D daily reduced opiod for Palliative Cancer - RCT 2021

‘Palliative-D’—Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial - July 2021
Cancers 2021, 13(15), 3707; https://doi.org/10.3390/cancers13153707
by Maria Helde Frankling 1,2ORCID,Caritha Klasson 1,2,3ORCID,Carina Sandberg 3,Marie Nordström 3,Anna Warnqvist 4,Jenny Bergqvist 5,6,Peter Bergman 7,8ORCID andLinda Björkhem-Bergman 1,2,3,*ORCID

Simple Summary
In this study, the effect of vitamin D supplementation on pain, infections, fatigue and quality of life in patients with advanced cancer with verified vitamin D deficiency was studied. To this end, a randomized controlled trial, ‘Palliative-D’, was conducted, comparing the effect of 4000 IU vitamin D3/day for 12 weeks to placebo in cancer patients admitted to palliative care. Pain was assessed as change in opioid dose and infections measured as days on antibiotics. Vitamin D-supplemented patients increased their opioid doses at a significantly slower rate than patients receiving placebo, i.e., 0.56 µg less fentanyl/h per week with vitamin D treatment. Vitamin D reduced self-assessed fatigue but did not affect antibiotic use or self-assessed Quality of life. The treatment was safe and well-tolerated. In conclusion, correction of vitamin D deficiency may have positive effects on pain and fatigue in palliative cancer patients.

Abstract
The aim of the ‘Palliative-D’ study was to test the hypothesis that correction of vitamin D deficiency reduces opioid use in cancer patients admitted to palliative care. A multicenter randomized, placebo-controlled, double-blind trial in three home-based palliative care facilities in Sweden was performed. Patients with advanced cancer and 25-hydroxyvitamin D < 50 nmol/L were randomized to vitamin D3 4000 IU/day or placebo for 12 weeks. The primary endpoint was the difference of long-acting opioid use (fentanyl ug/h) between the groups during 12 weeks, based on four time points. Secondary outcomes included changes in antibiotic use, fatigue and Quality of Life (QoL). A total of 244 patients were randomized, and 150 patients completed the 12 weeks. The major reason for drop-out was death due to cancer. The vitamin D-group had a significantly smaller increase of opioid doses compared to the placebo-group; beta coefficient −0.56 (p = 0.03), i.e., 0.56 µg less fentanyl/h per week with vitamin D treatment. Vitamin D-reduced fatigue assessed with ESAS was −1.1 points after 12 weeks (p < 0.01). Antibiotic use or QoL did not differ significantly between the groups. The treatment was safe and well-tolerated. In conclusion, correction of vitamin D deficiency may have positive effects on opioid use and fatigue in palliative cancer patients, but only in those with a survival time more than 12 weeks.
 Download the PDF from VitaminDWiki


The Effect of Vitamin D Supplementation on Treatment-Induced Pain in Cancer Patients: A Systematic Review - Aug 2022

Pain Management Nursing Volume 23, Issue 4, August 2022, Pages 458-466 https://doi.org/10.1016/j.pmn.2022.02.001
Mitra Zarrati PhD ⁎ † 1, Mohammad Hassan Sohouli PhD ‡ 1, Sahar Aleayyub MSc ⁎, Naeemeh Keshavarz PhD §, Elham Razmpoosh PhD ‖, Mihnea-Alexandru Găman MD ¶ #, Somaye Fatahi PhD ⁎, Heshmatolah Heydari PhD †† ‡‡

Objectives
Despite the widespread use of complementary and alternative medicine by patients and physicians alike, there is no accurate evidence regarding the effects of vitamin D supplementation on treatment-induced pain in cancer patients. Thus, the aim of this systematic review of randomized controlled trials (RCTs) was to evaluate the impact of vitamin D administration on therapy-related pain in subjects diagnosed with malignant disorders.

Review analysis methods
We searched the Web of Science, Scopus, PubMed/Medline, Embase, and Google Scholar databases up to October 2020 to identify published RCTs that investigated the use of vitamin D in the management of treatment-induced pain in individuals with cancer.

Results
Nine RCTs were detected. The median duration of the intervention was of 24 weeks (range 12-52 weeks) and dose of vitamin D employed was 2000-50000 IU of vitamin D3 weekly orally each day. Six RCTs reported a significant reduction in pain, whereas three did not detect a notable decrease of this variable. Of the six studies that reported an alleviation of pain, an RCT which recruited 60 participants and lasted for 24 weeks consisted of supplementation with high doses of vitamin D2 weekly for 8 weeks in women receiving anastrozole as adjuvant therapy, then supplementation with vitamin D2 monthly for 4 months, effectively alleviated the aromatase inhibitor-associated musculoskeletal syndrome (AIMSS). The results of the same RCT also suggested a beneficial effect of vitamin D on musculoskeletal pain.

Conclusions
Our results suggest that the supplementation with high doses of vitamin D in cancer patients with low serum levels of vitamin D, can be effective in reducing treatment-related pain.

Section snippets
Search Strategy
This systematic review was executed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement criteria (Moher et al., 2015). Relevant articles were retrieved from the following electronic databases: PubMed/Medline, Clarivate Analytics Web of Science, Scopus, Cochrane, Embase, and Google Scholar. The literature was systematically searched from the inception of these databases until October 2020 using several Medical Subject Headings (MeSH) terms

Results
From the 2,855 articles detected, a total of 9 RCTs were eligible for inclusion in this systematic review (Amir et al., 2010; Beer et al., 2004; Helde-Frankling et al., 2017; Khan et al., 2012; Khan et al., 2010; Niravath et al., 2019; Rastelli et al., 2011; Shapiro et al., 2016; Van Veldhuizen et al., 2000). A number of 2094 studies was excluded for the following reasons: no data on the levels of pain after treatment were reported, some articles did not evaluate treatment-induced pain in . . . .

Discussion
This is the first systematic review of RCTs to examine the effects of vitamin D supplementation on treatment-induced pain in cancer patients. Unfortunately, we were unable to perform a meta-analysis due to the limited number of interventional studies. . . . .

Our systematic review suggests that vitamin D supplementation in patients diagnosed with a malignancy may exhibit a positive impact on treatment-induced pain and may be able to lower pain especially in individuals with low levels of vitamin D. . . . .

Conclusions
Our results suggest that supplementation with high doses of vitamin D in cancer patients with low serum levels of vitamin D, administered after the initiation of AIs therapy, can be effective in reducing treatment-related pain in individuals diagnosed with a malignancy. Based on our findings, the administration of vitamin D in subjects who do not display vitamin D deficiency at baseline does not alleviate pain in cancer patients. . . . . .
References include

  • Switching breast cancer patients with progressive bone metastases to third-generation bisphosphonates: measuring impact using the Functional Assessment of Cancer Therapy-Bone Pain (2009)
  • Cost issues related to pain management: Report from the cancer pain panel of the agency for health care policy and research (1994)
  • Efficacy of complementary and alternative medicine therapies in relieving cancer pain: a systematic review

Journal of Clinical Oncology (2006)

  • Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain? A systematic review and meta-analysis (2017)
  • Vitamin D in pain management (2017)

33+ VitaminDWiki pages have FATIGUE or CFS in the title

This list is automatically updated

Items found: 34
Title Modified
Taking vitamin D reduced Lupus fatigue– Aug 2010 03 Sep, 2010
If less than 20 ng then 2X more likely to be fatigued after brain injury - April 2010 05 Nov, 2011
20000 IU vitamin D and MS – less fatigue and relapse Dec 2010 22 Feb, 2012
Hypothesis – vitamin D will decrease chronic inflammation and fatigue – Oct 2010 13 Jul, 2013
Chronic Fatigue Syndrome reduced with 25,000 IU of vitamin D weekly – June 2013 22 Nov, 2013
Chronic Fatigue and Vitamin D insight – Jan 2014 12 Jan, 2014
Muscle fatigue reduced with 10,000 IU of vitamin D – March 2013 05 May, 2014
Fatigue substantially reduced by 450,000 IU Vitamin D2 spread over 5 weeks – Aug 2014 06 Jan, 2015
Less fatigue if more vitamin D (90 percent of palliative cancer were deficient) – Aug 2015 03 Sep, 2015
2000 IU of vitamin D reduced fatigue of advanced cancer – RCT May 2012 03 Sep, 2015
Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015 24 Nov, 2016
Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016 27 Feb, 2017
Chronic Fatigue Syndrome reduced by D-Ribose – 2012 07 May, 2018
Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018 14 Jul, 2018
PMS: 1.5X more likely to have cramps, feel fatigued and anxious if low vitamin D – Sept 2018 03 Sep, 2018
8 Signs of Low Vitamin D - sweating, bones ache, muscle pain, poor immune, fatigue, slow healing etc. – YouTube Dec 2018 05 Aug, 2019
Fatigued seniors have lower levels of Vitamin D – Oct 2019 20 Oct, 2019
Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019 26 Nov, 2019
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 21 Feb, 2021
PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021 23 Sep, 2021
Adverse reactions to 100 Pfizer booster vaccinations: 83 pain, 63 fatigue, 48 headache, etc. - Sept 2021 13 Oct, 2021
Severe fatigue and headache in 4 pct of vaccinated, age 16-25 - Oct 2021 27 Oct, 2021
Post-stroke fatigue cut in half by Vitamin D (just 600 IU daily in 3 months) – Nov 2021 22 Nov, 2021
Epstein Barr Virus and Chronic Fatigue Syndrome 13 Dec, 2021
Chronic Fatigue Syndrome and long-haul COVID-19 26 Sep, 2022
Epstein-Barr Virus probably causes Long-COVID, CFS, and MS - many studies 02 Oct, 2022
Coronary Artery Disease Chest Pain, Anxiety, and Fatigue associated with low vitamin D – Oct 2022 07 Oct, 2022
Fatigue and other long-haul problems appear to be associated with low Magnesium - Chambers Oct 2022 30 Oct, 2022
Long-COVID fatigue reduced by Vitamin C and l-Arginine in one month– RCT Nov 2022 24 Nov, 2022
Overview Fibromyalgia or Chronic Fatigue and vitamin D 11 Jul, 2023
Multiple Sclerosis fatigue reduced by weekly Vitamin D (50,000 IU) – June 2023 15 Jul, 2023
Fibromyalgia pain, fatigue, etc. reduced by 50,000 IU of Vitamin D for 12 weeks – Sept 2023 04 Oct, 2023
Fatigue reduced by Vitamin D (Cancer, muscle, MS, age, etc) - many studies 12 Nov, 2023
SSRI Drugs Can Cause Chronic Fatigue Syndrome - Mercola April 2024 19 Apr, 2024

30+ VitaminDWiki Intervention pages with CANCER in title

This list is automatically updated

Items found: 30
Title Modified
Mayo clinic starting Cancer RCT using grossly inadequate 2,000 IU of vitamin D – Sept 2013 04 Dec, 2013
Breast Cancer reduced 20 percent by just 400 IU of vitamin D plus Calcium – 2011 15 Nov, 2014
Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012 14 Mar, 2015
Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011 16 Mar, 2015
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015 02 Apr, 2015
Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012 24 May, 2015
Colon Cancer proven again to not be treated by just 1000 IU of vitamin D – RCT Oct 2015 20 Oct, 2015
Low risk Prostate Cancer decreased with 4,000 IU of vitamin D – July 2012 21 Dec, 2015
Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP – Aug 2017 01 Sep, 2017
Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018 26 Sep, 2017
Lymphoid cancer deaths cut in half with 400 IU of vitamin D and 1 gram of Calcium (WHI) – RCT Nov 2017 04 Nov, 2017
Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021 28 Nov, 2017
Liver cancer nicely treated by high dose vitamin D for 16 weeks (early stage, in rats) – April 2018 23 Apr, 2018
Lung cancer treated by Vitamin D (1200 IU early stage) – RCT July 2018 04 Sep, 2018
Vitamin D and Omega-3 Ineffective for Preventing Cancer and Heart Disease (too little was used) – Nov 2018 21 Nov, 2018
Advanced Colorectal Cancer survival is increased somewhat with 4,000 IU of vitamin D – RCT April 2019 10 Apr, 2019
Digestive tract cancer death rates reduced a bit by a bit of vitamin D – RCT April 2019 10 Apr, 2019
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019 04 Jun, 2019
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies 14 Jun, 2019
Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019 07 Sep, 2019
2,000 IU of vitamin D and Omega-3 reduced Cancer death rate bv 40% (normal weight) – VITAL RCT Nov 2020 03 Dec, 2020
Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021 20 Jun, 2021
Digestive Tract Cancer survival increased 3X if 2,000 IU of vitamin D and have high level of PD-L1 – RCT June 2021 29 Jun, 2021
Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019 25 Jul, 2021
Rectal Cancer genes down-regulated by Vitamin D (3,200 IU only helped some) – RCT Aug 2021 03 Aug, 2021
Breast Cancer not prevented by 1,000 IU of Vitamin D (no surprise) – RCT Aug 2021 14 Apr, 2022
2.5 X reduced risk of cancer in 70 year-olds by a small amount of Vitamin D, Omega-3 and exercise – RCT April 2022 25 Apr, 2022
Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016 31 Dec, 2022
After Colorectal Cancer Surgery the immune system was maintained by Vitamin D (8,000 IU daily) – RCT Jan 2023 03 Jan, 2023
Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023 13 Aug, 2023

VitaminDWiki – Pain - chronic category contains:

161 items in category Chronic pain

See also



Attached files

ID Name Comment Uploaded Size Downloads
20359 Fitigue italian senior.png admin 12 Nov, 2023 28.49 Kb 111
20358 Fatigue corelatd to Low D in seniors.pdf admin 12 Nov, 2023 545.13 Kb 53
20357 Fatigue RCT.pdf admin 12 Nov, 2023 290.78 Kb 57
20356 Colorectal 3 charts.png admin 12 Nov, 2023 114.10 Kb 118
20355 higher d less fatigue colorectal_CompressPdf.pdf admin 12 Nov, 2023 226.11 Kb 55
20354 ‘Palliative-D’_CompressPdf.pdf admin 12 Nov, 2023 312.81 Kb 55
20353 Fatigue correction_CompressPdf.pdf admin 12 Nov, 2023 347.54 Kb 63
20352 Fatigue Cancer_CompressPdf.pdf admin 12 Nov, 2023 88.14 Kb 54