Toggle Health Problems and D

Vitamin D might increase lifespan – clinical trial with 5,000 mice - June 2021

Investigational drugs and nutrients for human longevity.
Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu

Expert Opinion on Investigational Drugs 2021 June 3 doi: 10.1080/13543784.2021.1939306
Ricardo P Garay

INTRODUCTION: Several pharmacological drugs have shown proof of concept for longevity in animal models. I aimed to identify and review those longevity drug candidates that are undergoing clinical trials.

AREAS COVERED: Recent (post-2017) longevity clinical trials were found in US and EU clinical trial registries. Longevity drug candidates are the antidiabetic drugs metformin and acarbose, and the immunosuppressant rapamycin. These medicinal drugs are tested on biochemical and clinical markers of aging. In addition, vitamin D supplementation is being investigated in two mega-trials (sample size> 5000) for its efficacy in reducing all-cause mortality.

EXPERT OPINION: Anti-aging effects of longevity drug candidates suggest, but do not demonstrate that they prolong life. The two megatrials with vitamin D supplementation make it possible to detect differences in life expectancy between vitamin D and placebo. Therefore, a protocol similar to that for vitamin D could be used to demonstrate pro-longevity effects of metformin, acarbose, and rapamycin.

PDF costs $90


Mortality starts with:

People die sooner if they have low vitamin D

Mortality is.gd/VitaminDMortality
click on image for details

There are 238 articles in Mortality category

The Meta-analysis of Mortality and Vitamin D are listed here:

Created by admin. Last Modification: Sunday June 6, 2021 01:29:11 GMT-0000 by admin. (Version 3)
See any problem with this page? Report it (FINALLY WORKS)