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Age-related loss of strength (Dynapenia) 1.7X more likely if low Vitamin D – Sept 2022


Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia?

Calcif Tissue Int. 2022 Sep 15.doi: 10.1007/s00223-022-01021-8
Maicon Luís Bicigo Delinocente 1 , Mariane Marques Luiz 2 , Dayane Capra de Oliveira 2 , Aline Fernanda de Souza 2 , Paula Camila Ramírez 2 3 , Roberta de Oliveira Máximo 2 , Natália Cochar Soares 4 , Andrew Steptoe 5 , Cesar de Oliveira 5 , Tiago da Silva Alexandre 6 7 8 9

Epidemiological evidence showing the association between low 25(OH)D and age-related reduction in neuromuscular strength (dynapenia) is a paucity and controversial and, to date, the effect of osteoporosis and vitamin D supplementation on these associations has not been measured. Thus, we analyze whether serum 25(OH)D deficiency and insufficiency are risk factors for the incidence of dynapenia in individuals aged 50 or older and whether osteoporosis or vitamin D supplementation modify these associations. For that, 3205 participants of the ELSA study who were non-dynapenic at baseline were followed for 4 years. Vitamin D was measured at baseline by the serum concentration of 25(OH)D and classified as sufficient (> 50 nmol/L), insufficient (≥ 30 and ≤ 50 nmol/L) or deficient (< 30 nmol/L). The incidence of dynapenia was determined by a grip strength < 26 kg for men and < 16 kg for women at the end of the 4-year follow-up. Poisson regression models were adjusted by sociodemographic, behavioral, clinical and biochemical characteristics. Serum 25(OH)D deficient was a risk factor for the incidence of dynapenia (IRR = 1.70; 95% CI 1.04-2.79). When only individuals without osteoporosis and those who did not use vitamin D supplementation were analyzed, both serum 25(OH)D deficiency (IRR = 1.78; 95% CI 1.01-3.13) and insufficiency (IRR = 1.77; 95% CI 1.06-2.94) were risk factors for the incidence of dynapenia.

In conclusion, a serum level of 25(OH)D < 30 nmol/L is a risk factor for the incidence of dynapenia. Among individuals without osteoporosis and those who do not take vitamin D supplementation, the threshold of risk is higher (≤ 50 nmol/L).
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VitaminDWiki Senior pages with STRENGTH in title (8 as of Sept 2022)

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VitaminDWiki Senior pages with SARCOPENIA in title (12 as of Sept 2022)

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ID Name Comment Uploaded Size Downloads
18436 Dynapenia.pdf PDF 2022 admin 16 Sep, 2022 13:29 584.80 Kb 12
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