Pediatr Allergy Immunol. 2011 Sep 19. doi: 10.1111/j.1399-3038.2011.01190.x.
van Oeffelen AA, Bekkers MB, Smit HA, Kerkhof M, Koppelman GH, Haveman-Nies A, van der A DL, Jansen EH, Wijga AH.
Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Center for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Center for Nutrition and Health, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Background:? Research suggests an influence of micronutrients on childhood asthma. So far, evidence mainly originates from cross-sectional studies using nutrient intake data, which is not an accurate measure of nutrient status. This study aimed to investigate the cross-sectional and prospective associations between serum concentrations of magnesium, vitamin D, selenium, and zinc and prevalence of (severe) asthma, atopy, and bronchial hyperresponsiveness (BHR) in childhood.
Methods:? In the Prevention and Incidence of Asthma and Mite Allergy birth cohort study, serum nutrient concentrations were available for a 4-yr-old subgroup (n?=?372) and for a different 8-yr-old subgroup (n?=?328). Yearly questionnaires inquired about asthma prevalence until 8?yr of age. Allergic sensitization was measured at 4 and 8?yr of age; BHR was measured at 8?yr of age. Data were analyzed with logistic regression and generalized estimating equations models.
Results:? There was a consistent (non-significant) inverse association between serum magnesium concentrations and asthma prevalence. Serum vitamin D concentrations measured at age 4 were inversely associated with asthma at ages 4-8 [e.g., cross-sectional association between vitamin D tertile 3 vs. 1 and severe asthma: odds ratio (OR): 0.49, 95% confidence interval (CI): 0.25-0.95], whereas vitamin D measured at age 8 was positively associated with asthma at age 8 (e.g., cross-sectional association between vitamin D tertile 3 vs. 1 and severe asthma: OR: 2.14, 95% CI: 0.67-6.82).
Conclusions:? Our study contributes to the evidence that children with higher serum magnesium concentrations are less likely to have asthma. The associations between serum vitamin D concentrations and asthma were age-dependent.
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Age 4 asthma worse if low vitamin D
Age 8 asthma worse if high vitamin D