JAMA Pediatr. 2019;173(8):736-743. doi:10.1001/jamapediatrics.2019.1327
Casey Crump, MD, PhD1,2; Elizabeth A. Howell, MD, MPP2,3,4; Annemarie Stroustrup, MD, MPH3,5; et al Mary Ann McLaughlin, MD2,6; Jan Sundquist, MD, PhD1,2,7; Kristina Sundquist, MD, PhD1,2,7
Options: Vitamin D/Omega-3 during pregnancy or after
Cut risk of preterm birth in half by taking Vitamin D during Pregnancy
Cut risk of preterm birth reduced by taking Omega-3 during Pregnancy
Cut risk of Heart Disease by Taking Vitamin D
Cut risk of Heart Disease by Taking Omega-3
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Healthy pregnancies need lots of vitamin D
- Number of articles in both categories Pregnancy and:
23 ; Depression 17 ; Diabetes 38 ; Obesity 11 ; Hypertension 33 ; Breathing 29 ; Omega-3 27 ; Vitamin D Receptor 14
- All items in category Infant/Child
- breastfed 887 items as of Jan 2018
- Preeclampsia 825 items as of Jan 2018
- Pre-term 4710 items as of Dec 2018
- "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
- Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 802 items as of Aug 2018
- postpartum depression 208 items as of Aug 2018
- Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 541 as of June 2018
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Feb 2017
- Fertility and Sperm category listing has
98 items along with related searches
- (Stunting OR “low birth weight” OR LBW) 505 items as of Jan 2018
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summaryProblem
Reduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limits
RCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT
RCT = Randomized Controlled Trial
- Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Preterm births 4 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- Note: There are many low-cost ways to improve the Vitamin D Receptor
- Preterm Births - promising preventions – anti-oxidants, Vitamin D, Omega-3, Zinc, etc. – Jan 2019
- Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019
Objective To determine whether preterm birth is associated with an increased risk of IHD in adulthood in a large population-based cohort.
Design, Setting, and Participants This national, population-based cohort study included all 2 141 709 persons who were born as singleton live births in Sweden during 1973 to 1994. The data were analyzed in September 2018.
Exposures Gestational age at birth, identified from nationwide birth records in the Swedish Birth Registry.
Main Outcomes and Measures Ischemic heart disease that was identified from nationwide inpatient and outpatient diagnoses through 2015 (maximum age, 43 years). A Cox regression was used to examine gestational age at birth in association with IHD in adulthood while adjusting for other perinatal and maternal factors. Cosibling analyses assessed for potential confounding by unmeasured shared familial factors.
Results Of 2 141 709 participants, 1 041 906 (48.6%) were female and there were 1921 persons (0.09%) who received a diagnosis of IHD in 30.9 million person-years of follow-up. Gestational age at birth was inversely associated with IHD risk in adulthood. At ages 30 to 43 years, adjusted hazard ratios for IHD associated with preterm (gestational age <37 weeks) and early-term birth (37-38 weeks) were 1.53 (95% CI, 1.20-1.94) and 1.19 (1.01-1.40), respectively, compared with full-term birth (39-41 weeks).
Preterm-born women had lower IHD incidence than preterm-born men (15.16 vs 22.00 per 100 000 person-years) but had a higher adjusted hazard ratio (1.93; 95% CI, 1.28-2.90 vs 1.37; 95% CI, 1.01-1.84). These associations did not appear to be explained by shared genetic or environmental factors in families.
Conclusions and Relevance In this large national cohort, preterm and early-term birth were associated with an increased IHD risk in adulthood. Persons born prematurely need early evaluation and preventive actions to reduce the risk of IHD.
- All items in category Infant/Child