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Immune system degrades with age (perhaps Vitamin D can help) - Jan 2022


Hallmarks of aging and immunosenescence: Connecting the dots

Immune system cells                    Changes with aging                    Implications
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Cytokine & Growth Factor Reviews Volume 59, June 2021, Pages 9-21. https://doi.org/10.1016/j.cytogfr.2021.01.006, PDF behind paywall
Leane PerimRodriguesaVitória RodriguesTeixeiraaThuanyAlencar-SilvaaBiancaSimonassi-PaivaabRinaldo WellersonPereiraaRobertPogueabJuliana LottCarvalhoac

Aging is a natural physiological process that features various and variable challenges, associated with loss of homeostasis within the organism, often leading to negative consequences for health. Cellular senescence occurs when cells exhaust the capacity to renew themselves and their tissue environment as the cell cycle comes to a halt. This process is influenced by genetics, metabolism and extrinsic factors. Immunosenescence, the aging of the immune system, is a result of the aging process, but can also in turn act as a secondary inducer of senescence within other tissues. This review aims to summarize the current state of knowledge regarding hallmarks of aging in relation to immunosenescence, with a focus on aging-related imbalances in the medullary environment, as well as the components of the innate and adaptive immune responses. Aging within the immune system alters its functionality, and has consequences for the person's ability to fight infections, as well as for susceptibility to chronic diseases such as cancer and cardiovascular disease. The senescence-associated secretory phenotype is described, as well as the involvement of this phenomenon in the paracrine induction of senescence in otherwise healthy cells. Inflammaging is discussed in detail, along with the comorbidities associated with this process. A knowledge of these processes is required in order to consider possible targets for the application of senotherapeutic agents - interventions with the potential to modulate the senescence process, thus prolonging the healthy lifespan of the immune system and minimizing the secondary effects of immunosenescence.


VitaminDWiki – Immunity category starts

262 items in Immunity category

    see also

Virus category listing has 1342 items along with related searches

Overview Influenza and vitamin D
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600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
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Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D

18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
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47 studies are in both Immunity and Virus categories

VitaminDWiki – Items in both categories Immunity and Seniors


VitaminDWiki – Items in both categories Virus and Immunity


Attached files

ID Name Comment Uploaded Size Downloads
16933 immune system.jpg admin 29 Jan, 2022 165.00 Kb 701
16932 immune system GRH.jpg admin 29 Jan, 2022 169.27 Kb 115