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Less able to understand language at age 2 if low vitamin D during second trimester – Dec 2015

Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study.

Nutrients. 2015 Dec 2;7(12):9918-30. doi: 10.3390/nu7125499.
Tylavsky FA1,2, Kocak M3, Murphy LE4,5, Graff JC6,7, Palmer FB8,9, Völgyi E10,11, Diaz-Thomas AM12, Ferry RJ Jr13,14.


Receptive Language = understand language
Ensure a healthy pregnancy and infant with as little as $20 of Vitamin D
More vitamin D during pregnancy made for higher mental scores at 14 months – Dec 2012
Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

40 nanogram increased vitamin D ==> Increase Receptive Language score by 1


Many variables increase Receptive Language score by at least 1

 Download the PDF from VitaminDWiki

Emerging data suggest that vitamin D status during childhood and adolescence can affect neurocognitive development. The purpose of this study was to investigate whether gestational 25(OH)D status is associated with early childhood cognitive and receptive language development. The Conditions Affecting Neurocognitive Development and Learning in Early Childhood Study (CANDLE) study enrolled 1503 mother-child dyads during the second trimester of healthy singleton pregnancies from Shelby County TN. Among 1020 participants of the total CANDLE cohort for whom 25(OH)D levels were available, mean gestational 25(OH)D level during the second trimester was 22.3 ng/mL (range 5.9-68.4), with 41.7% of values <20 ng/dL.

Cognitive and language scaled scores increased in a stair-step manner as gestational 25(OH)D levels in the second trimester rose from <20 ng/dL, through 20-29.99 ng/dL, to =30 ng/dL. When controlling for socioeconomic status, race, use of tobacco products, gestational age of the child at birth, and age at the 2-year assessment, the gestational 25(OH)D was positively related to receptive language development (p < 0.017), but not cognitive or expressive language.

Attached files

ID Name Comment Uploaded Size Downloads
7085 T2.jpg admin 16 Sep, 2016 16:24 111.59 Kb 379
7084 Receptive T3.jpg admin 16 Sep, 2016 16:24 53.67 Kb 390
7083 Receptive Language Development.pdf PDF 2015 admin 16 Sep, 2016 16:24 385.67 Kb 385
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