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Small for gestational age birth was 6.5X more likely if mother was vitamin D deficient – March 2015

Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population.

J Clin Endocrinol Metab. 2015 Mar 16:jc20144407. [Epub ahead of print]
Chen YH1, Fu L, Hao JH, Yu Z, Zhu P, Wang H, Xu YY, Zhang C, Tao FB, Xu X.
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CONTEXT:
Vitamin D deficiency is common in the pregnant women. Nevertheless, the association between maternal vitamin D status during pregnancy and the risks of small for gestational age (SGA) and low birth weight (LBW) infants is uncertain.

OBJECTIVE: The objective of this study was to investigate whether maternal vitamin D deficiency during pregnancy and the risks of SGA and LBW infants in Chinese population.

DESIGN AND PARTICIPANTS: This study was a population-based birth cohort study that recruited total 3658 eligible mother-and-singleton-offspring pairs.

MAIN OUTCOME MEASURES: Serum 25(OH)D was measured by radioimmunoassay. The rate and relative risk (RR) for SGA and LBW infants were calculated among subjects with vitamin D deficiency and insufficiency during pregnancy.

RESULTS:
There was a positive correlation between maternal serum 25(OH)D level and offspring birth weight (r=0.477, P<0.001). Further analysis showed that 4.98% neonates were LBW infants among subjects with vitamin D deficiency (RR: 12.00; 95%CI: 4.37, 33.00) and 1.32% among subjects with vitamin D insufficiency (RR: 3.18; 95%CI: 1.07, 9.48). After adjustment for confounders, RR for LBW infants was 12.31 (95%CI: 4.47, 33.89) among subjects with vitamin D deficiency and 3.15 (95%CI: 1.06, 9.39) among subjects with vitamin D insufficiency. Moreover, 16.01% neonates were SGA infants among subjects with vitamin D deficiency (RR: 5.72; 95%CI: 3.80, 8.59) and 5.59% among subjects with vitamin D insufficiency (RR: 1.99; 95%CI: 1.27, 3.13).
After adjustment for confounders, RR for SGA infants was 6.47 (95%CI: 4.30, 9.75) among subjects with vitamin D deficiency and 2.01 (95%CI: 1.28, 3.16) among subjects with vitamin D insufficiency.

CONCLUSION: Maternal vitamin D deficiency during pregnancy elevates the risks of SGA and LBW infants in Chinese population.

PMID: 25774884
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Attached files

ID Name Comment Uploaded Size Downloads
5191 SGA vs weeks Wikipedia.jpg admin 17 Mar, 2015 51.65 Kb 5184
5190 Gestational age mortality.jpg admin 17 Mar, 2015 38.25 Kb 1606
5189 SGA Mortality.jpg admin 17 Mar, 2015 30.84 Kb 1641
5188 SGA Dark Skin.jpg admin 17 Mar, 2015 41.45 Kb 1638
5187 SGA F1.jpg admin 17 Mar, 2015 45.12 Kb 2125
5186 small for gestational age.pdf admin 17 Mar, 2015 448.83 Kb 1677