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Preterm Births reduced by Omega-3, Zinc, and Vitamin D – Aug 2019

Preterm Birth: A Narrative Review of the Current Evidence on Nutritional and Bioactive Solutions for Risk Reduction.

Nutrients. 2019 Aug 6;11(8). pii: E1811. doi: 10.3390/nu11081811.
Samuel TM1, Sakwinska O1, Makinen K1, Burdge GC2, Godfrey KM3, Silva-Zolezzi I4.


Items in both categories Pregnancy and Omega-3 are listed here:

Items in both categories Pregnancy and Zinc are listed here:

Vitamin D and preterm birth

Preterm births are VERY costly – Feb 2017 contains this cost-analysis
Assumptions: additional $50,000 per premature birth, $100 for education & supplements per pregnancy

Net savings
per birth
After subtract
all cost
# needed
to eliminate
1 preterm
Cost of
educ, supp
per pregnancy
Total cost
Cost of
test per
Net savings after
subtract costs
Vitamin D
(5,000 IU avg)
$4,30020$100$2,000$200%%%(2 tests)$4,000$43,000
Omega-3 $64667 $100$6,700$0 $0 $43,300
Vitamin C
reduces early rupture
$64667$100$6,700$0$0 $43,300
Iodine $320100$100$10,000$80$8,000$32,000

Does not include additional savings to infant beyond the first year
   such as reductions in Autism, MS, Respiratory Tract Infection, Asthma, Allergies
Does not include additional savings to mother
   such as reduction in preeclampsia, miscarriage, gestational diabetes, depression
   nor does it assign any costs for anguish of possible premie death, stillbirth, time off from work, job productivity
Vitamin D helps more than preterm birth

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

 Download the PDF from VitaminDWiki

Preterm birth (PTB) (<37 weeks of gestation) is the leading cause of newborn death and a risk factor for short and long-term adverse health outcomes. Most cases are of unknown cause. Although the mechanisms triggering PTB remain unclear, an inappropriate increase in net inflammatory load seems to be key. To date, interventions that reduce the risk of PTB are effective only in specific groups of women, probably due to the heterogeneity of its etiopathogenesis. Use of progesterone is the most effective, but only in singleton pregnancies with history of PTB. Thus, primary prevention is greatly needed and nutritional and bioactive solutions are a promising alternative. Among these, docosahexaenoic acid (DHA) is the most promising to reduce the risk for early PTB. Other potential nutrient interventions include the administration of zinc (possibly limited to populations with low nutritional status or poor zinc status) and vitamin D; additional preliminary evidence exists for vitamin A, calcium, iron, folic acid, combined iron-folate, magnesium, multiple micronutrients, and probiotics. Considering the public health relevance of PTB, promising interventions should be studied in large and well-designed clinical trials. The objective of this review is to describe, summarize, and discuss the existing evidence on nutritional and bioactive solutions for reducing the risk of PTB.

Created by admin. Last Modification: Saturday October 26, 2019 15:37:43 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12449 PTB 3.pdf PDF 2019 admin 09 Aug, 2019 16:33 667.66 Kb 202
12448 PTB reduction - Table 3.jpg admin 09 Aug, 2019 16:30 124.82 Kb 190
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