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Risk of preterm birth twice as likely when less than 10 ng of vitamin D – Nov 2016

The Correlation Between Serum Vitamin D Deficiency and Preterm Birth.

Med Sci Monit. 2016 Nov 16;22:4401-4405.

VitaminDWiki

Strangely the study says there was no association, but their table shows that those having less than 10 nanograms of vitamin D were twice as likely to have a preterm birth. Perhaps it was because the likelihood of finding that result was not statistically significant (p = 0.06 rather than p< 0.02)

Pregnancy category starts with

721 items in Pregnancy category

 - see also

Healthy pregnancies need lots of vitamin D has the following summary__

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Image
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Yang L1, Pan S2, Zhou Y2, Wang X2, Qin A2, Huang Y2, Sun S1.

  • 1 Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China (mainland).
  • 2 Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Preterm birth is an important cause of death and developmental disorder in neonates. Vitamin D deficiency has been shown to regulate body inflammatory factor levels that stimulate elevation of uterine contraction hormones, such as prostaglandin, thus causing preterm birth. However, current observations regarding the relationship between vitamin D and preterm birth are inconsistent. We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.

MATERIAL AND METHODS A prospective cohort study included 200 cases of pregnant women in our hospital from May 2013 to May 2015. Blood samples were collected from early, middle, and late stages of pregnancy. Forty-six patients with preterm delivery were compared with age-matched full-term delivery cases (N=92). High performance liquid chromatography-mass spectrometry (HPLC-MS) was used to detect serum levels of 25(OH)D, 25(OH)D2, and 25(OH)D3. Logistic regression was performed to analyze the correlation between 25(OH)D and risk of preterm birth. R

ESULTS No significant difference in age, smoking/drinking, education level, BMI and vitamin D levels was found between the preterm birth group and full-term delivery group. No significant difference was found for vitamin D levels across different stages of pregnancy; no difference in concentration of 25(OH)D related to preterm birth risk was found. After adjusting for potentially confounding factors, serum vitamin D level did not increase the risk of preterm birth.

CONCLUSIONS This study did not found evidence of an increase in preterm birth risk related to vitamin D level during pregnancy.
PMID: 27851719 PMCID: PMC5117241

Attached files

ID Name Comment Uploaded Size Downloads
7915 Preterm birth China.pdf PDF 2016 admin 13 Apr, 2017 11:55 259.32 Kb 146
7914 PTB 10 ng.jpg admin 13 Apr, 2017 11:54 39.60 Kb 116
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