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Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019

Omega-3 polyunsaturated fatty acid intake norms and preterm birth rate: a cross-sectional analysis of 184 countries

BMJ Open http://dx.doi.org/10.1136/bmjopen-2018-027249
Timothy H Ciesielski1,2,3, Jacquelaine Bartlett1,3, Scott M Williams1,3

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Significantly fewer Preterm Births in countries with higher Omega-3 consumption


Map of Omega-3 consumption by countries


Background The preponderance of evidence now indicates that elevated long-chain omega-3 polyunsaturated fatty acid (LC omega-3 PUFA) intake is often associated with reduced risk of preterm birth (PTB). This conclusion is based on recent meta-analyses that include several studies that reported null findings. We probed the reasons for this heterogeneity across studies and its implications for PTB prevention using country-level data.

Methods We analysed the relationship between national PTB rates (<37 weeks of gestation) and omega-3 PUFA intake norms from 184 countries for the year 2010. To estimate the total LC omega-3 PUFA levels (eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]) that these norms produce we utilised a metric that accounts for

  • (1) seafood-based omega-3 intake (EPA/DHA) and
  • (2) plant-based omega-3 intake (alpha-linolenic acid [ALA]),
    • ~20% of which is converted to EPA/DHA in vivo.

We then assessed the shape of the omega-3–PTB relationship with a penalised spline and conducted linear regression analyses within the linear sections of the relationship.

Results Penalised spline analyses indicated that PTB rates decrease linearly with increasing omega-3 levels up to ~600 mg/day. Income-adjusted linear regression analysis among the countries in this exposure range indicated that the number of PTBs per 100 live births decreases by 1.5 (95% CI 2.8 to 0.3) for each 1 SD increase in omega-3 intake norms (383 mg/day).

Conclusions Taken with prior evidence for a causal association on the individual level, our findings indicate that omega-3 PUFA deficiency may be a widespread contributing factor in PTB risk. Consideration of baseline omega-3 PUFA levels is critical in the design of future interventions.

VitaminDWiki Omega-3 pages with PRETERM of PRE-TERM in title (13 as of May 2022)

This list is automatically updated

Items found: 16
Title Modified
Omega-3 supplementation reduced preterm birth rate by 4X – RCT July 2020 21 Oct, 2022
Preterm birth decreased by Omege-3, etc. - many studies 21 Oct, 2022
Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019 15 May, 2022
Preterm Births - promising preventions – anti-oxidants, Vitamin D, Omega-3, Zinc, etc. – Jan 2019 15 May, 2022
Preterm birth reduction by nutrients - Vitamin D is the best, Omega-3 is next best – May 2022 15 May, 2022
Preterm birth rate of pregnant smokers cut in half if take Omega-3 – RCT May 2017 20 Feb, 2022
Pre-term birth rate cut in half with 1000 milligrams of Omega-3 (if initially low) – RCT May 2021 04 Jun, 2021
Pregnant women in Australia to take Omega-3 when told of reduction in preterm births – Dec 2019 19 Nov, 2019
Preterm Births reduced by Omega-3, Zinc, and Vitamin D – Aug 2019 09 Aug, 2019
Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019 27 Apr, 2019
Omega-3 index of 5 greatly decreases the risk of an early preterm birth – Dec 2018 04 Jan, 2019
Increasing Omega-3 reduces heart problems, autism, depression, preterm birth, breast cancer, etc. 15 Dec, 2017
Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc 13 Nov, 2017
Preterm birth extended by 2 weeks with Omega-3 – Meta-analysis Nov 2015 10 Dec, 2016
Omega-3 supplementation during pregnancy reduce early preterm births (save 1500 USD per child) – Aug 2016 12 Oct, 2016
Omega-3 helps pregnancy in many ways: preterm 26 percent less likely etc – review July 2012 08 Sep, 2015

Created by admin. Last Modification: Sunday May 15, 2022 14:47:35 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
11831 Omega-3 map.jpg admin 27 Apr, 2019 13:20 37.79 Kb 504
11830 PTB Omegs-3.jpg admin 27 Apr, 2019 13:20 14.42 Kb 494
11829 PTB Omegs-3l.pdf PDF 2019 admin 27 Apr, 2019 13:19 675.39 Kb 450