Research prioritization of interventions for the primary prevention of preterm birth: An international survey.
Eur J Obstet Gynecol Reprod Biol. 2019 Jan 25. pii: S0301-2115(19)30048-X. doi: 10.1016/j.ejogrb.2019.01.021.
Allotey J1, Matei A2, Husain S3, Newton S4, Dodds J5, Armson AB2, Khan KS5, Vogel JP6.
- Preterm births are VERY costly – Feb 2017
- Preterm birth rate reduced by vitamin D – 78 percent if non-white, 39 percent if white – July 2017
- Omega-3 index of 5 greatly decreases the risk of an early preterm birth – Dec 2018
- Pre-term birth rate of pregnant smokers cut in half if take Omega-3 – RCT May 2017
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Typical pregnancy is now 39 weeks – Omega-3 and Vitamin D might restore it to full 40 weeks
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Vitamin D Receptor
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- Preterm birth far more likely if previous miscarriage and poor Vitamin D receptor – Aug 2017
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
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5 (1.0) Affordability to women The intervention will be affordable to women 5 (1.0) Affordability to HCP The intervention will be affordable to health careproviders 5 (1.0) Acceptability to women The intervention will be acceptable to women 5 (0) Acceptability to HCP The intervention will be acceptable to health careproviders 5 (1.0) Implementation The intervention can be implemented 5 (1.0) Sustainability The intervention can be sustained in the long-term 4 (2.0) Equity The intervention will reach the most vulnerablegroups and reduce health inequity 4 (2.0) Effectiveness of an RCT An RCT on this intervention is likely to demonstrate desirable or beneficial effects 5 (1.0) Feasibility of an RCT An RCT on this intervention would be feasible 5 (1.0 Summary Score
Vitamin D, Omega-3, etc
To identify research priorities of interventions for the primary prevention of preterm birth (PTB), by conducting an international stakeholder survey.
A prospective cross-sectional online survey was conducted in November 2016. Fifteen interventions to prevent spontaneous PTB were identified and ranked by stakeholders (n = 159) in the field of maternal and perinatal health research, using nine equally weighted criteria. Medians and interquartile ranges (IQRs) were calculated and the interventions ranked accordingly.
Respondents to the survey were from 46 different countries, mostly from low and middle-income countries (62%, 99/159) and were mainly clinicians (80%, 127/159). Of the fifteen interventions ranked, the following five were identified as research priorities in the primary prevention of PTB: dietary counselling and nutritional education, risk scoring, vitamin D supplementation, exercise and antioxidant supplementation.
We have identified research priorities of interventions to prevent spontaneous PTB through a global stakeholder survey. The interventions prioritized in this exercise can be used by researchers, grant funding bodies and research-policy decision makers to inform calls on future clinical trials or individual patient data meta-analyses on the primary prevention of PTB.
Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019
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