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Preterm infants more likely to have vitamin D levels below 20 ng – Feb 2014

Vitamin D status among preterm and full-term infants at birth

Pediatric Research (2014) 75, 75–80 doi:10.1038/pr.2013.174
Heather H. Burris, Linda J. Van Marter, Thomas F. McElrath, Patrik Tabatabai, Augusto A. Litonjua, Scott T. Weiss & Helen Christou

Background:
Risk factors for maternal vitamin D deficiency and preterm birth overlap, but the distribution of 25-hydroxyvitamin D (25(OH)D) levels among preterm infants is not known. We aimed to determine the associations between 25(OH)D levels and gestational age.

Methods:
We measured umbilical cord plasma levels of 25(OH)D from 471 infants born at Brigham and Women’s Hospital in Boston. We used generalized estimating equations to determine whether preterm (<37 wks’ gestation) or very preterm (<32 wks’ gestation) infants had greater odds of having 25(OH)D levels below 20 ng/ml than more mature infants. We adjusted for potential confounding by season of birth, maternal age, race, marital status, and singleton or multiple gestation.

Results:
Mean cord plasma 25(OH)D level was 34.0 ng/ml (range: 4.1–95.3 and SD: 14.1). Infants born before 32 wks’ gestation had increased odds of having 25(OH)D levels below 20 ng/ml in unadjusted (odds ratio (OR): 2.2; 95% confidence interval (CI): 1.1–4.3) and adjusted models (OR: 2.4; 95% CI: 1.2–5.3) as compared with more mature infants.

Conclusion:
Infants born in <32 wks’ gestation are at higher risk than more mature infants for low 25(OH)D levels. Further investigation of the relationships between low 25(OH)D levels and preterm birth and its sequelae is thus warranted.



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Text Clipped from PDF
In the United States, very preterm delivery (<32 wk) is more than twice as common among black infants (3.9%) compared with white infants (1.6%) (33).


PDF is attached at the bottom of this page

See also VitaminDWiki

IU Cumulative Benefit Blood level CofactorsCalcium $*/month
200 Better bones for mom
with 600 mg of Calcium
6 ng/ml increase Not needed No effect $0.10
400 Less Rickets (but not zero with 400 IU)
3X less adolescent Schizophrenia
Fewer child seizures
20-30 ng/ml Not needed No effect $0.20
2000 2X More likely to get pregnant naturally/IVF
2X Fewer dental problems with pregnancy
8X less diabetes
4X fewer C-sections (>37 ng)
4X less preeclampsia (40 ng vs 10 ng)
5X less child asthma
2X fewer language problems age 5
42 ng/ml Desirable < 750 mg $1
4000 2X fewer pregnancy complications
2X fewer pre-term births
49 ng/ml Should have
cofactors
< 750 mg $3
6000 Probable: larger benefits for above items
Just enough D for breastfed infant
More maternal and infant weight
Should have
cofactors
< 750 mg $4

Pre-term birth costs $51,800 (vs. very little cost of vitamin D to prevent one: 10% of births are pre-term)

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click on chart for detailed information

Attached files

ID Name Comment Uploaded Size Downloads
3593 Preterm F3.jpg admin 03 Feb, 2014 12:39 34.37 Kb 1066
3592 Preterm F2.jpg admin 03 Feb, 2014 12:38 42.40 Kb 1007
3591 Pretern Burris Feb 2014.pdf PDF 2014 admin 03 Feb, 2014 12:38 338.54 Kb 744
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