Loading...
 
Translate Register Log In Login with facebookLogin and Register

Preemies need 1,000 IU of vitamin D – RCT Sept 2017

Two items on this page

Multi-dose vitamin d supplementation in stable very preterm infants: Prospective randomized trial response to three different vitamin D supplementation doses

Early Human Development. Volume 112, September 2017, Pages 54–59
ttps://doi.org/10.1016/j.earlhumdev.2017.07.016
Ozlem Bozkurt, dr_kalyoncu at hotmail.com, Nurdan Uras, Fatma Nur Sari, Funda Yavanoglu Atay, Suzan Sahin, Ayse Dogan Alkan, Fuat Emre Canpolat, Serife Suna Oguz
Highlights

  • There is no consensus regarding the adequate dose of supplementation for preterm infants.
  • Vitamin D supplementation of 1000 IU/d in very preterm infants effectively decreases the prevalence of vitamin D deficiency.
  • The clinical importance of biochemically sufficient levels of vitamin D need to be further assessed.
VitaminDWiki Summary

121 premies (< 33 weeks) with low vitamin D (< 20 ng) given Vitamin D for 36 weeks

400 IU800 IU1000 IU
Vitamin D achieved by half 29 ng 40 ng43 ng

See also VitaminDWiki


Background
Preterm newborns are born with lower vitamin D stores. Although vitamin D supplementation is recommended there is no consensus regarding the adequate dose of supplementation for preterm infants.

Aims
To assess the effect of three different doses of vitamin D supplementation (400, 800 and 1000 IU/d) in preterm infants ≤ 32 weeks gestation on the prevalence of vitamin D deficiency and 25(OH) D levels at 36 weeks postmenstrual age (PMA).

Study design: Prospective randomized trial.

Subjects: 121 preterm infants with gestational age of 24–32 weeks were randomly allocated to receive 400, 800 or 1000 IU/d vitamin D.

Outcome measures
Serum concentration of 25(OH) D and the prevalence of vitamin D deficiency at 36 weeks PMA. Vitamin D deficiency was defined as serum 25(OH) D concentrations < 20 ng/ml.

Results
Of the 121 infants 72% had deficient vitamin D levels before supplementation. The average 25(OH) vitamin D concentrations at 36 weeks PMA were significantly higher in 800 IU (40 ± 21.4 ng/ml) and 1000 IU group (43 ± 18.9 ng/ml) when compared to 400 IU group (29.4 ± 13 ng/ml). The prevalence of vitamin D deficiency (2.5 vs 22.5; RR: 0.09; CI:0.01–0.74) and insufficiency (30 vs 57.5; RR:0.32; CI:0.13–0.80) was significantly lower in 1000 IU group when compared to 400 IU group at 36 weeks PMA.

Conclusion
1000 IU/d of vitamin D supplementation in preterm infants ≤ 32 weeks gestation age effectively decreases the prevalence of vitamin D deficiency and leads to higher concentrations of 25(OH) vitamin D at 36 weeks PMA

Trial registration Clinical Trials.gov: NCT02941185.


800 IU provided benefits to premies, 400 IU did not - RCT 2017

Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population
 Download the PDF from VitaminDWiki

Created by admin. Last Modification: Tuesday October 10, 2017 21:38:29 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
8534 Preemie RCT 800 IU.pdf PDF 2017 admin 10 Oct, 2017 21:33 1.27 Mb 98
See any problem with this page? Report it (FINALLY WORKS)