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Supplement preterm infants with vitamin D if less than 80 ng – RCT Sept 2021

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Nutrients 2021, 13(10), 3442; https://doi.org/10.3390/nu13103442
Alicja Kołodziejczyk-Nowotarska ORCID,Renata Bokiniec andJoanna Seliga-Siwecka *
Department of Neonatology and Neonatal Intensive Care, Medical University of Warsaw, 00-315 Warsaw, Poland



VitaminDWiki pages containing PRETERM or PREMIE in title

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Items found: 88
Title Modified
Preterm birth rate increased in US but decreased in Finland (high Vitamin D) - Jan 2024 09 Feb, 2024
Off Topic: Xylitol reduces cavities, preterm births, osteoporosis, RTI, obesity, diabetes, etc. - several studies 01 Jan, 2024
Preterm birth chance reduced –17P (expensive drug) or Vitamin D – June 2015 01 Jan, 2024
Preterm birth and low Vitamin D - many studies 24 Dec, 2023
Preterm births are VERY costly – Feb 2017 24 Dec, 2023
Preterm birth cost for employers approximately 50,000 dollars – Oct 2017 24 Dec, 2023
Preterm Birth 2.7X more likely if low vitamin D (dark skin in this case) - Nov 2023 01 Nov, 2023
4.4 X more likely to have a preterm birth if low vitamin D while pregnant (India) - May 2022 01 Nov, 2023
Omega-3 supplementation reduced preterm birth rate by 4X – RCT July 2020 21 Oct, 2022
Preterm birth decreased by Omege-3, etc. - many studies 21 Oct, 2022
Arab preterm infants often have less than 10 ng of vitamin D - 2010 15 May, 2022
Preterm birth interventions – 4 studies found possible vitamin D benefit – Cochrane – Nov 2018 15 May, 2022
Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019 15 May, 2022
Preterm Births - promising preventions – anti-oxidants, Vitamin D, Omega-3, Zinc, etc. – Jan 2019 15 May, 2022
Preterm birth reduction by nutrients - Vitamin D is the best, Omega-3 is next best – May 2022 15 May, 2022
Preterm birth rate of pregnant smokers cut in half if take Omega-3 – RCT May 2017 20 Feb, 2022
Preterm birth varies with season: 25 percent more likely if conception in autumn – Feb 2022 04 Feb, 2022
Supplement preterm infants with vitamin D if less than 80 ng – RCT Sept 2021 28 Sep, 2021
Preterm infants need Vitamin D 04 Aug, 2021
Preterm birth risk increased 16 pcnt if heat wave (perhaps outside less) - Nov 2020 16 Nov, 2020

Infant-Child category has 816 items and starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

  • Sun is great – well known for 1,000’s of years.
    US govt (1934) even said infants should be out in the sun
  • One country recommended 2,000 IU daily for decades – with no known problems
  • As with adults, infants and children can have loading doses and rarely need tests
  • Daily dose appears to be best, but monthly seems OK
  • Vitamin D is typically given to infants in the form of drops
       big difference in taste between brands
       can also use water-soluable form of vitamin D in milk, food, juice,
  • Infants have evolved to get a big boost of vitamin D immediately after birth
    Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
  • 100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
    More than 100 IU/kg is probably better

 Download the PDF from VitaminDWiki

Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20−80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.

Clipped from PDF
“Eighty percent of calcium and phosphorus placental transfer occurs between 24–40 weeks of gestation; hence, preterm infants are especially prone to adverse effects of VDD, including MBD and low bone mineral status [21,34,35].”

Created by admin. Last Modification: Tuesday September 28, 2021 19:20:35 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
16311 pretern.jpg admin 28 Sep, 2021 31.55 Kb 260
16310 Preterm supplementation.pdf admin 28 Sep, 2021 983.28 Kb 246