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Sepsis in first year of life is much more likely if preterm (low Vitamin D) – May 2017

Neonatal and Maternal 25-OH Vitamin D Serum Levels in Neonates with Early-Onset Sepsis

Children 2017, 4(5), 37; doi:10.3390/children4050037

VitaminDWiki Summary

Vitamin D Levels (nanograms)

(34 weeks)
Full term
(37.5 weeks)
Infants 2.6176.5 X
Mothers 10 20 2 X

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

It appears that low premie vitamin D predicted with 95% accuracy that the infant would have sepsis in the first year

"In our study, both of neonatal and maternal 25-OH vitamin D serum levels were good sensitive markers (84% and 82%, respectively) and good specific tests (79% and 77%, respectively) with positive predictive values (94.7% and 91.4%, respectively) and negative predictive values (82.3% and 80.6%, respectively) for early detection of neonatal sepsis, and these are in agreement with many previous studies"

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Taha Soliman Gamal 1, Abd-Allah Sayed Madiha 1, Mostafa Kamel Hanan 2, Mohamed El-Mazary Abdel-Azeem 1,* and Gamil S. Marian 1
1 Pediatric Department, El-Minya University, Minya, 11432, Egypt
2 Clinical-Pathology Department; El-Minya University, Minya 11432, Egypt

Vitamin D is a fat-soluble vitamin that is important for calcium metabolism and plays an important role in the immune functions. The aim of this study was to measure neonatal and maternal 25-OH vitamin D serum levels in neonates with early onset sepsis. The study included fifty neonates with early onset sepsis (25 full-term and 25 preterm infants) and thirty age and sex matched healthy neonates as controls. After history taking and clinical examination, complete blood count, C-reactive protein and 25-OH vitamin D serum levels (neonatal and maternal) were measured for all neonates.
The mean gestational age for neonates with sepsis was (37.5 ± 0.98 for full term and 34.1 ± 1.26 for preterm neonates).
Neonatal and maternal 25-OH vitamin D serum levels were significantly lower in patients (6.4 ± 1.8 and 24.6 ± 2.2 nmol/L) than controls (42.5 ± 20.7 and 50.4 ± 21.4 nmol/L).
Significant negative correlations between neonatal and maternal 25-OH vitamin D serum levels and all sepsis markers and significant positive correlations between neonatal and maternal 25-OH vitamin D levels were present. At cut-off values <20 nmol/L for neonatal and <42 nmol/L for maternal 25-OH vitamin D for detection of neonatal sepsis, the sensitivity, specificity, positive predicted value (PPV) and negative predicted value (NPV) were 84%, 79%, 94.7% and 82.3% for neonatal and 82%, 77%, 91.4% and 80.6% for maternal 25-OH vitamin D, respectively.

Positive correlations between neonatal and maternal 25-OH Vitamin D serum levels are present and they are negatively correlated with all sepsis markers. They can be sensitive early predictors for early onset sepsis in neonates.

Attached files

ID Name Comment Uploaded Size Downloads
7976 Early-Onset Sepsis.pdf PDF 2017 admin 10 May, 2017 16:58 912.15 Kb 620