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Preterm Births - promising preventions – anti-oxidants, Vitamin D, Omega-3, Zinc, etc. – Jan 2019

Research prioritization of interventions for the primary prevention of preterm birth: An international survey

Eur J Obstet Gynecol Reprod Biol. 2019 Jan 25. pii: S0301-2115(19)30048-X. doi: 10.1016/j.ejogrb.2019.01.021.
Allotey J1, Matei A2, Husain S3, Newton S4, Dodds J5, Armson AB2, Khan KS5, Vogel JP6.

VitaminDWiki

International Survey ranked the possibilities
Vitamin D was the only supplement which was a research priority

Note: For thousands of years pregnancies averaged 40 weeks
In 2006 March of Dimes stated the average pregnancy lasted only 39 weeks (new average)


Vitamin D helps before, during, and after pregnancy

Pregnancy category starts with

667 items in Pregnancy category

 - see also


Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial


Items in both categories Pregnancy and Omega-3 are listed here:

Items in both categories Pregnancy and Zinc are listed here:

 Download the PDF from Sci-Hub via VitaminDWiki

Top 8 promising interventions to reduce pre-term births

1 Antioxidants 1 Supplementation Regular antenatal dietary supplementation
of one or more antioxidants such as vitamin C
2 Vitamin D 2 SupplementationRegular antenatal dietary supplementation of vitamin D
either alone or in combination with other supplements
3 Vitamin E 3 SupplementationRegular antenatal dietary supplementation of vitamin E
either alone or in combination with other supplements
4 Omega-3/fish oil 4 Supplementation Regular antenatal dietary supplementation of Omega-3/fish oil capsules
5 Zinc 5 SupplementationRegular antenatal dietary supplementation of zinc
either alone or in combination with other supplements
6 Aspirin 6 Supplementation Low-dose aspirin therapy with or without dipyridamole
7 Probiotics 7 Supplementation Regular administration of probiotics
as pessaries capsules, tablets or powder
8 Antibiotics prophylaxis 8 Treatment of infectionRoutine antibiotics given during the second and third trimesters
to prevent vaginal or cervical infections

OBJECTIVE:
To identify research priorities of interventions for the primary prevention of preterm birth (PTB), by conducting an international stakeholder survey.

STUDY DESIGN:
A prospective cross-sectional online survey was conducted in November 2016. Fifteen interventions to prevent spontaneous PTB were identified and ranked by stakeholders (n = 159) in the field of maternal and perinatal health research, using nine equally weighted criteria. Medians and interquartile ranges (IQRs) were calculated and the interventions ranked accordingly.

RESULTS:
Respondents to the survey were from 46 different countries, mostly from low and middle-income countries (62%, 99/159) and were mainly clinicians (80%, 127/159).
Of the fifteen interventions ranked, the following five were identified as research priorities in the primary prevention of PTB:

  • dietary counselling and nutritional education,
  • risk scoring,
  • vitamin D supplementation,
  • exercise and
  • antioxidant supplementation.

Criteria
Image
CONCLUSION:
We have identified research priorities of interventions to prevent spontaneous PTB through a global stakeholder survey. The interventions prioritized in this exercise can be used by researchers, grant funding bodies and research-policy decision makers to inform calls on future clinical trials or individual patient data meta-analyses on the primary prevention of PTB.

Created by admin. Last Modification: Monday March 4, 2019 18:03:15 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
11515 Research priorities.jpg admin 04 Mar, 2019 16:47 90.69 Kb 24
11514 Preterm possibilities sci-hub.pdf PDF 2019 admin 04 Mar, 2019 16:06 641.57 Kb 6
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