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60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018

Vitamin D and Its Role in Neonatal Hypoxic-Ischemic Brain Injury

Neonatology 2018;113:305–312, https://doi.org/10.1159/000486819
Stessman L.E. · Peeples E.S.


This study speculates as to how much Vitamin D should be given during pregnancy to reduce HIE

Healthy pregnancies need lots of vitamin D has the following summary

Infant Hypoxic Ischemic Encephalopathy (HIE)

  • "Hypoxic Ischemic Encephalopathy (HIE) is a type of brain damage that occurs when an infant’s brain doesn’t receive enough oxygen and blood."
  • " the incidence rate in premature babies is 60% of all live births"
    The word vitamin does not occur once on that page

Hypoxic-Ischemic Encephalopathy Medscape Jan 2018

  • "Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia"
  • "Birth asphyxia causes 840,000 or 23% of all neonatal deaths worldwide"

Hypoxic-Ischemic Encephalopathy, or HIE, also known as Intrapartum Asphyxia Cerebralpalsy.org

  • "Oxygen deprivation, or intrapartum asphyxia, can cause Cerebral Palsy. One of the most common types of brain damage caused by oxygen loss is called hypoxic-ischemic encephalopathy, or HIE. When HIE occurs, it often leads to severe developmental or cognitive delays, or motor impairments that become more apparent as the child continues to develop"


Emerging evidence has demonstrated that vitamin D plays an important role in many adult neurologic disorders, but is also critical in neuronal development and pruning in the neonatal and pediatric populations. Neonates are at a particularly high risk of vitamin D deficiency, in part due to the high prevalence of maternal deficiency during pregnancy. Several preclinical studies have demonstrated that infants born to vitamin D-deficient mothers are at a high risk of developing neonatal brain injury, and recent clinical studies have shown that neonates with hypoxic-ischemic encephalopathy (HIE) tend to be vitamin D-deficient. There are limited data, however, on whether additional prenatal or postnatal supplementation may alter the prevalence or severity of neonatal HIE. This review examines the current data supporting the neuroprotective role of vitamin D, with a focus on how these findings may be translated to neonates with HIE.

 Download the PDF from VitaminDWiki

Created by admin. Last Modification: Thursday February 22, 2018 00:00:43 UTC by admin. (Version 3)
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ID Name Comment Uploaded Size Downloads
9386 HIE Fig 4.jpg admin 21 Feb, 2018 23:49 40.54 Kb 41
9385 HIE.pdf admin 21 Feb, 2018 23:48 249.95 Kb 21
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