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Vaginal microbiome varies with race, vitamin D level, preterm birth, etc. - March 2019

Relationship between vitamin D status and the vaginal microbiome during pregnancy

Journal of Perinatology (2019) https://doi.org/10.1038/s41372-019-0343-8
Kimberly K. Jefferson, Hardik I. Parikh, Erin M. Garcia, David J. Edwards, Myrna G. Serrano, Martin Hewison, Judith R. Shary, Anna M. Powell, Bruce W. Hollis, Jennifer M. Fettweis, Jerome F. Strauss III, Gregory A. Buck & Carol L. Wagner

Objective
Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome.

Study design
Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D 25(OH)D concentrations were examined.

Result
Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance.

Conclusion: Certain vaginal bacteria are associated with plasma 25(OH)D concentration.

The first dozen References – all of which are online

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