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Omega-3 index of 5 greatly decreases the risk of an early preterm birth – Dec 2018

A Prenatal DHA Test to Help Identify Women at Increased Risk for Early Preterm Birth: A Proposal

Nutrients 2018, 10(12), 1933; doi:10.3390/nu10121933
Kristina H. Jackson * and William S. HarrisOrcID
OmegaQuant, LLC, 5009 W. 12th St., Suite 8, Sioux Falls, SD 57106, USA

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Fish intake and docosahexaenoic acid (DHA), a nutrient found in fish, have been favorably linked to several pregnancy outcomes. The risk of early preterm birth (ePT, <34 weeks gestation) is associated with low fish intake and DHA blood levels and can be reduced by supplemental DHA. Here, we summarize the evidence linking blood DHA levels with risk for ePT birth, and based on the available studies, propose that women who are pregnant or trying to become pregnant aim for a red blood cell (RBC) DHA value of at least 5% (of total RBC fatty acids). In the US, ~70% of women of childbearing age are likely below this cut-point, and dietary intake data suggest that this group, including pregnant women, consumes ~60 mg/day DHA and that >90% of this group do not take an omega-3 supplement. Since the recommendations for women to consume fish and to take a 200 mg DHA supplement during pregnancy are not being heeded generally, there is a need to motivate practitioners and pregnant women to attend to these recommendations. Having an objective prenatal blood DHA test could provide such motivation. More research is needed to test the clinical utility of this proposed target prenatal DHA level.

PDF Table of contents

Relationship between Maternal DHA Levels and Preterm Birth
Is an RBC DHA of >5% a Reasonable Target?
Are There Risks Associated with an RBC DHA >5% in Pregnancy?
How Might a Target RBC DHA Level Be Used in Obstetric Practice?
Why Not Just Recommend Higher DHA Intake to Everyone and Not Test?
Possible Mechanisms for a DHA Effect on Early Preterm Birth

40 pages listed in BOTH the categories Omega-3 and Pregnancy

This list is automatically updated

Vitamin D reduces preterm pregnancy costs

Pregnancy category starts with

891 items in Pregnancy category

 - see also

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Preterm births are VERY costly – Feb 2017 cost-analysis of Vitamin D and Omega-3

Assumptions: additional $50,000 per premature birth, $100 for education & supplements per pregnancy

Net savings
per birth
After subtract
all cost
# needed
to eliminate
1 preterm
Cost of
educ, supp
per pregnancy
Total cost
Cost of
test per
Net savings after
subtract costs
Vitamin D
(5,000 IU avg)
$4,30020$100$2,000$200%%%(2 tests)$4,000$43,000
Omega-3 $64667 $100$6,700$0 $0 $43,300
Vitamin C
reduces early rupture
$64667$100$6,700$0$0 $43,300
Iodine $320100$100$10,000$80$8,000$32,000

Does not include additional savings to infant beyond the first year
   such as reductions in Autism, MS, Respiratory Tract Infection, Asthma, Allergies
Does not include additional savings to mother
   such as reduction in preeclampsia, miscarriage, gestational diabetes, depression
   nor does it assign any costs for anguish of possible premie death, stillbirth, time off from work, job productivity

Created by admin. Last Modification: Wednesday October 5, 2022 11:53:49 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
11144 DHA PT Birth.jpg admin 04 Jan, 2019 24.79 Kb 436
11143 DHA preterm.pdf admin 04 Jan, 2019 731.05 Kb 570