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Omega-3 supplementation during pregnancy reduce early preterm births (save 1500 USD per child) – Aug 2016

Docosahexaenoic acid supplementation (DHA) and the return on investment for pregnancy outcomes

PLEFA August 2016 Volume 111, Pages 8–10; DOI: http://dx.doi.org/10.1016/j.plefa.2016.05.008 |
T.I. Shireman1, E.H. Kerling, B.J. Gajewski, J. Colombo, S.E. Carlson
1Present address: The Department of Health Services, Policy & Practice, Brown University, Providence, RI, USA.


It appears that Omega-3 reduces EARLY preterm birth while Vitamin D reduces preterm birth

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial
Also: Omega-3 Reduces Stillbirth 3 times RCT
The items in Pregnancy and Omega-3 are listed here:

•Early preterm birth (ePTB) occurs before 34 weeks gestation.
•ePTB cost the US approximately USD 10.6 Billion in 2014.
•Public policy effort to increase DHA intake of pregnant women is important.

The Kansas University DHA Outcomes Study (KUDOS) found a significant reduction in early preterm births with a supplement of 600 mg DHA per day compared to placebo. The objective of this analysis was to determine if hospital costs differed between groups. We applied a post-hoc cost analysis of the delivery hospitalization and all hospitalizations in the following year to 197 mother-infant dyads who delivered at Kansas University Hospital. Hospital cost saving of DHA supplementation amounted to $1678 per infant. Even after adjusting for the estimated cost of providing 600 mg/d DHA for 26 weeks ($166.48) and a slightly higher maternal care cost ($26) in the DHA group, the net saving per dyad was $1484. Extrapolating this to the nearly 4 million US deliveries per year suggests universal supplementation with 600 mg/d during the last 2 trimesters of pregnancy could save the US health care system up to USD 6 billion.

Publisher wants $36 for the PDF

Also reported at Nutragredients save US $6 billion annually

58% reduction in early preterm birth: reduce costs from $10 billion to $4 billion