Is vitamin d deficiency a risk factor for respiratory distress syndrome?
Int J Vitam Nutr Res. 2013;83(4):232-7. doi: 10.1024/0300-9831/a000165.
Ataseven F1, Aygün C2, Okuyucu A3, Bedir A4, Kücük Y5, Kücüködük S2.
BACKGROUND:
Previous studies have shown the relationship between in utero lung development and vitamin D [25(OH)D], but there have been no studies to investigate whether vitamin D deficiency is a risk factor for respiratory distress syndrome (RDS) in preterm babies.
OBJECTIVES:
In this study, we investigated if 25(OH)D deficiency is a risk factor for RDS.
METHODS:
One hundred fifty-two preterm newborns, born at 29 - 35 weeks gestational age, were included in the study following informed consent from the parents. Peripheral blood samples were collected within the first 24 hours of life and 25(OH)D levels were measured by liquid chromatography-tandem mass spectrometry. Demographic characteristics of the babies and the diagnosis of RDS were recorded.
RESULTS:
- In 64 % of preterm infants, 25(OH)D levels were compatible with severe deficiency (≤ 10 ng/mL),
- 33 % with moderate deficiency (10 - 20 ng/mL), and
- 3 % with mild deficiency (20 - 30 ng/mL).
In none of the babies was a normal 25(OH)D level observed. Serum 25(OH)D levels were not correlated with gestational age. Respiratory distress syndrome was more common in preterm babies with severe (28 %) compared to mild-moderate 25(OH)D deficiency (14 %) (p < 0.05).
CONCLUSIONS:
None of the preterm infants in this study had normal vitamin D level, which underlined the burden of vitamin D deficiency in pregnant women and their offspring. RDS was more common in severely vitamin D-deficient preterms. Determination of vitamin D status of the mothers and appropriate supplementation might be a valuable strategy to reduce RDS, in addition to antenatal steroids. Besides, since vitamin D is a regulatory factor in many organs during fetal development, long-term effects of in utero vitamin D deficiency warrant further studies.
PMID: 25008013
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See also VitaminDWiki
- Immature lungs in immature newborns – Vitamin D helps – Sept 2018
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
Pages listed in BOTH the categories Infant-Child and Breathing
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- Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021
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- Gene that predicts wheezing is associated with low vitamin D – Oct 2019
- Bronchiolitis in children associated with both pollution and low solar – July 2019
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
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- Bronchiolitis had 1.3 X longer hospitalization if low Vitamin D (1016 infants) – Sept 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Childhood pneumonia not treated by 100,000 IU of vitamin D – Cochrane (need more, inhaled) – July 2018
- Pneumonia is increasing (now 1 in 6 child deaths), more vitamin D studies needed – June 2018
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- Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018
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- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
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- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017
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