Pediatric Research (2019) https://doi.org/10.1038/s41390-019-0322-y
Danforth A. Newton, John E. Baatz, Mark S. Kindy, Sebastiano Gattoni-Celli, Judy R. Shary, Bruce W. Hollis & Carol L. Wagner
Items in both categories infant-child and Vitamin D Binding Protein are listed here:
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018
- Vitamin D is more bio-available when children are critically ill (less Binding Protein) – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
- Vitamin D Binding Protein category listing has
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Poor Vitamin D binding had 30 percent less response to Vitamin D (50,000 IU weekly) – Feb 2019
- Epilepsy 1.4 X more likely if poor Vitamin D Binding Protein (Han Chinese) – July 2018
- Response to Vitamin D varies with Vitamin D Binding Protein gene – RCT May 2018
Polymorphic alleles of the vitamin D (vitD)-binding protein (VDBP) gene are associated with discriminatory differences in circulating concentrations of 25-hydroxyvitamin D (25-D), the indicator of vitD status (sufficiency defined by the Endocrine Society as ≥75 nmol/L). Within a diverse group of children, we hypothesized that reaching recommended daily allowance (RDA) of vitD intake would have differential impact on vitD status depending on VDBP variability.
VDBP alleles (Gc1S, Gc1F, Gc2) in 123 children (1–4 annual visits/child; ages 1–8 years) were compared for relationships with serum 25-D concentrations and daily vitD intake.
In African-American children, reaching the vitD RDA was associated with significantly higher mean serum 25-D concentrations for the 20% carrying the VDBP 1S allele than for the large majority without this allele (77 vs. 61 nmol/L 25-D; p = 0.038). Children with the Gc1S/1S homozygous genotype (30% Caucasians, 24% Hispanics, 2% African-Americans) who met RDA had 51% (39 nmol/L) greater mean serum 25-D than those below RDA (p < 0.0001).
VDBP genetic variability was a significant factor affecting childhood vitD status when following RDA guidelines. This study may inform public health policy of uniformity in recommended childhood vitD dosage, especially regarding racially/ethnically associated disparities.
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