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During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020

Vitamin D-Binding Protein in Pregnancy and Reproductive Health

by Melinda Fernando 1,Stacey J. Ellery 2OrcID,Clara Marquina 1OrcID,Siew Lim 1,Negar Naderpoor 1,† andAya Mousa 1, aya.mousa at monash.edu,†OrcID

  • 1 Monash Centre for Health Research and Implementation (MCHRI) and Centre of Cardiovascular Research and Education in Therapeutics (CCRET), School of Public Health and Preventive Medicine, Monash University, Melbourne 3168 VIC, Australia
  • 2 The Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynaecology, Monash University, Melbourne 3168 VIC, Australia



Pages listed in BOTH the categories Pregnancy and Vitamin D Binding Protein

Vitamin D Binding Protein category listing has 174 items and the following introduction

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

  • GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
  • The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
  • The actual D getting to the cells is a function of measured D and all 4 genes
  • There is >2X increase in 8+ health problems if have poor VDBP (GC)
  • It appears that VDBP only blocks oral vitamin D,

Note: Topical Vitamin D does not appear to be blocked by VDBP

in Visio for 2023

Vitamin D Binding Protein has a list of health problems

Health Problem
11 XPreeclampsia
6.5XT1D in SA Blacks
6 XFood Allergy
4 X, 5XKidney Cancer
4 XPoor Response to Oral Vitamin D
3 XEar infection
2 X MS
2 X Colorectal Cancer
2 XProstate Cancer -in those with dark skins
1.3 XInfertility

Pregnancy category starts with

864 items in Pregnancy category

 - see also

 Download the PDF from VitaminDWiki

Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM). Improved methods for measuring VDBP and an increased understanding of its role in biological processes have led to a number of newly published studies exploring VDBP in the context of pregnancy. Here, we synthesize the available evidence regarding the role of VDBP in reproductive health and pregnancy, and we highlight areas requiring further study. Overall, low levels of maternal serum VDBP concentrations have been associated with infertility, endometriosis, PCOS and spontaneous miscarriage, as well as adverse pregnancy outcomes including GDM, pre-eclampsia, preterm birth and fetal growth restriction. However, increased VDBP concentration in cervicovaginal fluid has been linked to unexplained recurrent pregnancy loss and premature rupture of membranes. Some genetic variants of VDBP have also been associated with these adverse outcomes. Further studies using more accurate VDBP assays and accounting for ethnic variation and potential confounders are needed to clarify whether VDBP is associated with reproductive health and pregnancy outcomes, and the mechanisms underlying these relationships

Created by admin. Last Modification: Wednesday May 20, 2020 13:51:08 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
13827 VDBPTable B.jpg admin 20 May, 2020 13:50 213.16 Kb 404
13826 VDBPTable A.jpg admin 20 May, 2020 13:47 723.46 Kb 394
13825 VDBP F1.jpg admin 20 May, 2020 13:25 27.87 Kb 559
13824 Vitamin D-Binding Protein in Pregnancy.pdf PDF 2020 admin 20 May, 2020 13:25 536.17 Kb 493