Loading...
 
Toggle Health Problems and D

Major depression associated with vitamin D Binding Protein in youths – March 2018

Bipolar disorder in youth is associated with increased levels of vitamin D-binding protein.

Transl Psychiatry. 2018 Mar 13;8(1):61. doi: 10.1038/s41398-018-0109-7.
Petrov B1, Aldoori A1, James C2, Yang K1,3, Algorta GP4, Lee A1, Zhang L2, Lin T5, Awadhi RA6, Parquette JR5, Samogyi A2, Arnold LE7, Fristad MA7, Gracious B7,8, Ziouzenkova O9.

VitaminDWiki

VDBP

Intervention of Vitamin D for Depression


Meta-analyses of Vitamin D and Depression


10 most recently added items in Depression category in VitaminDWiki

Id Page Hits Last modification Creator Categories
12534 Trials using 1K to 14K IU of Vitamin D to treat depression had different conclusions – meta-analysis Jan 2021 75
25 Apr, 2021 01:32
admin Depression
Meta-analysis of Vitamin D
12468 Mental health of children: vast majority of studies reviewed found that vitamin D helped – March 2021 107
03 Apr, 2021 23:06
admin Depression
Infant-Child
Bipolar
12191 Iranian children and youths with low vitamin D have many health complaints – Jan 2021 186
04 Jan, 2021 12:48
admin Depression
Headache
Middle East
Youth
Sleep
Infant-Child
Back pain
12171 ADHD 3.7 X higher risk if depressed pregnancy (low vitamin D) – Dec 2020 216
23 Dec, 2020 02:55
admin Pregnancy
Depression
ADHD
12003 Risk of Major Depressive Disorder increased 2.2 X by a poor Vitamin D receptor – Oct 2020 348
10 Oct, 2020 13:53
admin Depression
Vitamin D Receptor
11987 2.3 X increase in COVID-19 death if mentally ill (associations: Mental Illness and Low Vitamin D, Low D and COVID-19 ... 418
04 Oct, 2020 15:42
admin Depression
Virus
11951 Depression strongly associated with low Vitamin D – Review Jan 2020 306
12 Sep, 2020 22:25
admin Depression
11915 Vitamin D reduced depression – single 300,000 IU – RCT Aug 2020 513
23 Oct, 2020 20:10
admin Depression
Loading dose for Vitamin D
11657 Middle Eastern women living in Sweden 23X higher risk to be anxious if low vitamin D – Feb 2020 552
03 Mar, 2020 14:13
admin Depression
Vitamin D Far from equator
Middle East
11651 Depression in psychiatric youths reduced 28 percent after just 1 month of vitamin D – RCT Feb 2020 596
27 Feb, 2020 17:16
admin Depression
Intervention

 Download the PDF from VitaminDWiki
Image

Image

Venn diagram (overlap) of MDD with PTSD, Alcohol Use Disorder and Anxiety

Image

Genetic, dietary, and inflammatory factors contribute to the etiology of major mood disorders (MMD), thus impeding the identification of specific biomarkers to assist in diagnosis and treatment. We tested association of vitamin D and inflammatory markers in 36 adolescents with bipolar disorder (BD) and major depressive disorder (MDD) forms of MMD and without MMD (non-mood control). We also assessed the overall level of inflammation using a cell-based reporter assay for nuclear factor kappa-B (NFκB) activation and measuring antibodies to oxidized LDL. We found that these factors were similar between non-mood and MMD youth. To identify potential biomarkers, we developed a screening immunoprecipitation-sequencing approach based on inflammatory brain glia maturation factor beta (GMFβ). We discovered that a homolog of GMFβ in human plasma is vitamin D-binding protein (DBP) and validated this finding using immunoprecipitation with anti-DBP antibodies and mass spectrometry/sequencing analysis. We quantified DBP levels in participants by western blot. DBP levels in BD participants were significantly higher (136%) than in participants without MMD (100%). The increase in DBP levels in MDD participants (121.1%) was not statistically different from these groups. The DBP responds early to cellular damage by binding of structural proteins and activating inflammatory cells. A product of enzymatic cleavage of DBP has been described as macrophage-activating factor. Circulating DBP is comprised of heterogenous high and low molecular fractions that are only partially recognized by mono- and polyclonal ELISA and are not suitable for the quantitative comparison of DBP in non-mood and MDD participants.
Our data suggest DBP as a marker candidate of BD warranting its validation in a larger cohort of adolescent and adult MMD patients.


Created by admin. Last Modification: Tuesday October 15, 2019 11:38:06 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
11037 MDD comorbidity.jpg admin 14 Dec, 2018 03:34 22.92 Kb 517
11036 MDD features.jpg admin 14 Dec, 2018 03:33 57.79 Kb 389
11032 MDD BP.jpg admin 13 Dec, 2018 15:37 15.38 Kb 373
11031 Bipolar disorder binding protein.pdf PDF 2018 admin 13 Dec, 2018 15:36 895.95 Kb 206
See any problem with this page? Report it (FINALLY WORKS)