Overview Cancer and vitamin D

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Scores of studies show that Vitamin D prevents many cancers and treats a few cancers

• Prevention results from 2,000 to 5,000 IU of vitamin D
  Prevention really depends on the level of vitamin D in the blood, and some vitamin D deficient groups need much more
• Treatment needs > 8,000 IU of vitamin D
  But must be careful, as vitamin D makes some Chemotherapy more potent

A high percentage of all cancer deaths are prevented by a high enough level of vitamin D in your bloodstream

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Vitamin D fights cancer in many ways - GrassrootsHealth Sept 2022

How Vitamin D Works to Help Prevent Cancer

• Inhibits cancer cell growth and proliferation
• Reduces cancer metastasis
• Stimulates maturation of healthy cells (differentiation)
• Induces death of cancer cells (apoptosis or programmed cell death)
• Prevents blood vessel growth in tumors (angiogenesis)
• Prevents inflammation associated with cancer
• Reduces the risk of incidence and/or death due to cancer

See also (VitaminDWiki)

• Palliative care is helped by Vitamin D - many studies
• Chemotherapy might be amplified by vitamin D
• Cancer and Cancer therapy often lower vitamin D levels
  • Lower Vitamin D levels increase the risk of many health problems

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Vitamin D and cancer clinical trials: 29 in VitaminDWiki, 453 in Clinical Trials.gov (Sept 2022)

Intervetion pages with CANCER in title
This list is automatically updated

Cancer Intervention Trials with Vitamin D 452 of Sept 2022

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VitaminDWiki - Infant-Child pages with CANCER in title (10 as of April 2022)

This list is automatically updated

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See also at VitaminDWiki: Cancer – Breast 242 items which includes

• Overview Breast Cancer and Vitamin D
• Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
• Breast Cancer chance decreased 16 percent for every extra ng of vitamin D – Jan 2013
• Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
• (Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
• Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019
• Half of Breast Cancer patients opt for vitamin D (German survey) – Jan 2021

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See also at VitaminDWiki: Cancer – Colon 134 items which includes

• Overview Cancer-Colon and vitamin D
• Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021
• Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
• Early-Onset Colorectal Cancer 2X less likely if consume 450 IU of Vitamin D daily (1 million person years)– Aug 2021
• Death from Colon Cancer 8 X less likely if good level of vitamin D – Nov 2018

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See also at VitaminDWiki: Cancer – Prostate 97 items- which includes

• Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021
• Reduce Prostate Cancer Risk: 1.3 X if eat specific plants, 1.7X if add Vitamin D
• BPH (PSA) decreased by Vitamin D (50,000 IU bi-weekly) – RCT Nov 2020
• Prostate cancer risk cut in half by consuming Boron-rich food or water
• Men with High Omega-3 ratio 3 times less likely to have high grade prostate cancer – July 2019
• Vitamin D, Sunlight, and the Epidemiology of Prostate Cancer – Jan 2013
• Advanced prostate cancer 2X more likely if low vitamin D – Sept 2012
• Surviving Prostate Cancer - Book June 2012
• Overview Prostate Cancer and Vitamin D
• Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015
• 59 % more likely to die of Prostate Cancer if very low on vitamin D – April 2011
• 16 % less Prostate Cancer sometimes for each 10ng vitamin D increase - Jan 2011
• 40,000 IU vitamin D daily reduced prostate cancer growth the most – April 2012

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See also at VitaminDWiki: Cancer – Pancreatic 54 items- which includes

• People consuming more Vitamin K1 were 40 percent less likely to get Pancreatic Cancer – Oct 2021
• Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018
• Pancreatic Cancer risk increased 24 percent for every 100 mg less of Magnesium intake – Dec 2015
• Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
• Restoring vitamin D levels to Pancreatic patients required up to 20000 IU daily – May 2012
• Far fewer Pancreatic Cancer deaths at stage III and IV with more than 20 ng vitamin D – Sept 2013
• Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
• Pancreatic cancer 30 percent less likely in Australians who got lots of UVB (vitamin D) – Dec 2013

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See also at VitaminDWiki: Cancer – Lung 53 items which includes

• Overview Lung cancer and vitamin D
• Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis Nov 2020
• Smoking reduces vitamin D - many studies
• Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021
• Lung and Vitamin D – Special Issue Dec 2011
• Vitamin A may hinder vitamin D benefits associated with Lung Cancer – July 2013
• Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis Sept 2015
• Low vitamin D strongly related to death due to tobacco cancer, but not others – March 2013

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See also at VitaminDWiki: Cancer - After 97 items which includes

• Cancer deaths of senior women 60 percent more likely if low Vitamin D – March 2015
• 3X less pelvic inflammation from cancer radiation if high level of vitamin D – Feb 2015

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See also at VitaminDWiki: Cancer – Skin 116 items

• Overview Suntan, melanoma and vitamin D
• Melanoma might be suppressed by Vitamin D - many studies
• Cancers reduced by Vitamin D (Skin cancer in this review) – Dec 2022
• Skin Cancer (SCC) minimized if get sun time around noon – Nov 2015
  Higher UVB to UVA ratio in the middle of the day
• Alzheimer disease 5X less likely with nonmelanoma skin cancer (lots of vitamin D) – May 2013
• 18X increased destruction of skin cancers if active vitamin D added to photodynamic therapy (mice) – March 2015

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See also at VitaminDWiki: Cancer – Lymphoma 23 items

• Lymphoma, leukemia etc, survival poor if low vitamin D – meta-analysis March 2015
• Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
• Some childhood cancer 30% less likely in parts of California with more UVB – April 2013

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See also at VitaminDWiki: Cancer – General, others 256 items

• Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
• Vitamin D and Risk of Rarer Cancers – Jan 2013
• Death of women from cancer 24 percent less likely if 20 ng more vitamin D – meta-analysis Sept 2013
• Some childhood cancer 30% less likely in parts of California with more UVB – April 2013
• Advanced stage cancer 3X more likely if low level of vitamin D – March 2012
• Vitamin D even repairs some genes – Jan 2012
  Strong hint as to why Vitamin D prevents and treats so many different types of cancer
• VitaminDWiki Blog post: How vitamin D deals with Cancer Feb 2012
• Low UVB is associated with 15 types of Cancer – Jan 2012
• Less Solar Radiation was associated with more Cancer - 1941

Following graph from the CDC August 2010

CLICK HERE for Original study by Lappe - 2007
41 minutes good video of Lappe explaining the trial
in which she mentions the next 5 year trial underway with 2,000 IU of vitamin D
Breast Cancer details from the study
For years 2-4
Placebo: 8 Breast Cancers out of 266 women
1100 IU vitamin D + Calcium 4 Breast Cancers out of 403 women
That is 8/266 ==> 4/403 with vitamin D
So roughly 3% ==> 1% with 1100 IU of vitamin D
about a 3X reduction for Breast Cancer(vs 4X reduction for all Cancers)
CLICK HERE for Lappe -2011 slide description of original study

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Colon Cancer Chart: Vitamin D > 40ng is good

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Increase in Childhood Cancer in recent decades

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Cancer $creening Doesn't Save Lives, Meta-Study Reveals - Jan 2015

Cancer $creening Doesn't Save Lives, Meta-Study Reveals
Huge problem of false positives/overdiagnosis GreenMedInfo Jan 2015

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The Impact of Vitamin D in Cancer - book chapter - 2017

 Download the PDF from VitaminDWiki

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Alternative therapies have worse outcomes when cancer therapy is ignored - July 2018

Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers
Skyler B. Johnson, MD1; Henry S. Park, MD, MPH1; Cary P. Gross, MD2; et al James B. Yu, MD, MHS1,2
JAMA Oncol. Published online July 19, 2018. doi:10.1001/jamaoncol.2018.2487
 Download the PDF from VitaminDWiki
"Vitamin D" does not occur once in the study
Note: Study only looks at
Cancer treatment, not prevention
Cancer mortality, not cancer survival

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Cancer Factoids from The Body, by Bill Bryson, 2019

• They (Cancers) have evolved to avoid detection,” says Vormoor. “They can hide from drugs. They can develop resistance. (VitaminDWiki also believes that many have also learned to hide
• Something we have only recently realized is that before cancers metastasize, they are able to prepare the ground for an invasion in distant target organs, probably through some form of chemical signaling. “What this means,” Vormoor says, “is that when cancer cells spread to other organs, they don’t just turn up and hope for the best. They already have a base camp
• Viruses and bacteria cause cancers, too. The World Health Organization in 2011 estimated that 6 percent of cancers in the developed world but 22 percent in low- and middle-income countries are attributable to viruses alone.
• A significant fraction of childhood cancer deaths come not from the cancer itself but from the treatments for it.

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Aloe appears to help with Cancer chemo and radiation therapy - Greger - July 2022

Aloe Is Put to the Test Against Cancer
Also mentions Aloe treating eye cancer in an individual - without any surgery or other treatment
Note: The wife of the founder of VitaminDWiki used several aloe plants to treat her Breast Cancer radiation therapy burns about 20 years ago.

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Cancer incidence in men and women, and Vitamin D ( 2022)

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