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Glioma (brain, spinal cancer) 40 percent less likely if male vitamin D levels were high 15 years earlier – Aug 2015

Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma.

Nutr Cancer. 2015;67(7):1120-30. doi: 10.1080/01635581.2015.1073757. Epub 2015 Aug 28.
Zigmont V1, Garrett A1, Peng J2,3, Seweryn M4, Rempala GA4, Harris R1, Holloman C5, Gundersen TE6, Ahlbom A7, Feychting M7, Johannesen TB8, Grimsrud TK8, Schwartzbaum J1.
1a Comprehensive Cancer Center and Division of Epidemiology, College of Public Health , Ohio State University , Columbus , Ohio , USA.
2b Division of Epidemiology , College of Public Health, Ohio State University , Columbus , Ohio , USA.
3c Nationwide Children's Hospital , Columbus , Ohio , USA.
4d Division of Biostatistics, College of Public Health and Mathematical Biosciences Institute , Ohio State University , Columbus , Ohio , USA.
5e Department of Statistics , Ohio State University , Columbus , Ohio , USA.
6f Vitas Analytic Services , Oslo , Norway.
7g Institute of Environmental Medicine , Division of Epidemiology, Karolinska Institutet , Stockholm , Sweden.
8h Department of Registration , Cancer Registry of Norway , Oslo , Norway.

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          Males and Females                       Males

There are no previous studies of the association between prediagnostic serum vitamin D concentration and glioma. Vitamin D has immunosuppressive properties; as does glioma. It was, therefore, our hypothesis that elevated vitamin D concentration would increase glioma risk. We conducted a nested case-control study using specimens from the Janus Serum Bank cohort in Norway. Blood donors who were subsequently diagnosed with glioma (n = 592), between 1974 and 2007, were matched to donors without glioma (n = 1112) on date and age at blood collection and sex. We measured 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D availability, using liquid chromatography coupled with mass spectrometry. Seasonally adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for each control quintile of 25(OH)D using conditional logistic regression. Among men diagnosed with high grade glioma >56, we found a negative trend (P = .04).

Men diagnosed = 56 showed a borderline positive trend (P = .08). High levels (>66 nmol/L) of 25(OH)D in men >56 were inversely related to high grade glioma from

  • =2 yr before diagnosis (OR = 0.59; 95% CI = 0.38, 0.91) to
  • =15 yr before diagnosis (OR = 0.61; 95% CI = 0.38,0.96).

Our findings are consistent long before glioma diagnosis and are therefore unlikely to reflect preclinical disease.

PMID: 26317248

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