Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006.
Levine ME1, Suarez JA2, Brandhorst S2, Balasubramanian P2, Cheng CW2, Madia F3, Fontana L4, Mirisola MG5, Guevara-Aguirre J6, Wan J2, Passarino G7, Kennedy BK8, Wei M2, Cohen P2, Crimmins EM1, Longo VD9.
Note: This study does not seem to discuss meat with/without antibiotics, roundup, etc.
Dialing Down the Grim Reaper Gene July 2019
- "But did you notice that it says not among older individuals? All of this is covered in my video Increasing Protein Intake After Age 65."
- "But if you look at the actual study, you’ll see that’s simply not true. Those eating lots of animal protein didn’t have four times more risk of dying from diabetes; they had 73 times the risk"
- M E Levine, J A Suarez, S Brandhorst, P Balasubramanian, C W Cheng, F Madia, L Fontana, M G Mirisola, J Guevara-Aguirre, J Wan, G Passarino, B K Kennedy, M Wei, P Cohen, E M Crimmins, V D Longo.Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 4;19(3):407-17.
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Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.