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Melanoma 25 X more likely if low vitamin D – Feb 2018

25-Hydroxyvitamin D serum levels and melanoma risk: a case-control study and evidence synthesis of clinical epidemiological studies.

Eur J Cancer Prev. 2018 Feb 12. doi: 10.1097/CEJ.0000000000000437. [Epub ahead of print]
Cattaruzza MS1, Pisani D2, Fidanza L3, Gandini S4, Marmo G3, Narcisi A3, Bartolazzi A5,6, Carlesimo M3.

Note: Virtually no melanoma for Vitamin D levels > 40 ng, which is easily obtained


 Download the PDF from Sci-Hub via VitaminDWiki

There is accumulating evidence that the vitamin D pathway may play a role in melanoma. The aim of this study was to investigate the association between 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of cutaneous melanoma.
A case-control study with 137 incident cases of melanoma (serum samples collected at the time of diagnosis) and 99 healthy controls (serum samples collected between October and April) was carried out and evaluated in the framework of an evidence synthesis of clinical epidemiological studies on the topic to facilitate comparisons and summarize the scientific evidence produced so far.
There was a statistically significant difference in the median levels of serum vitamin D between melanoma patients and healthy controls (18.0 vs. 27.8 ng/ml, P<0.001). Among melanoma patients, 66.2%, compared with 15.2% of healthy controls, had vitamin D deficiency (≤20 ng/ml), whereas vitamin D sufficiency (≥30 ng/ml) was observed in only 7.4% of melanoma patients and in 37.4% of the healthy controls (P<0.001).
A multivariate model including age, sex, and BMI showed a statistically significant inverse association between melanoma and vitamin D sufficiency versus deficiency (odds ratio=0.04; 95% confidence interval: 0.02-0.10, P<0.001).
Also, vitamin D insufficiency versus deficiency was significantly inversely associated with melanoma (odds ratio=0.13; 95% confidence interval: 0.06-0.27, P<0.001).
These results suggest that both deficient and insufficient serum levels of vitamin D are associated with melanoma and that a trend seems to be present with a reduced risk of melanoma when vitamin D approaches normal values.

PMID: 29438161 DOI: 10.1097/CEJ.0000000000000437

Study was reported on by Grassroots Health in June 2018


Created by admin. Last Modification: Saturday March 13, 2021 14:40:07 GMT-0000 by admin. (Version 13)

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ID Name Comment Uploaded Size Downloads
10052 Melanoma.jpg admin 29 Jun, 2018 21:02 36.28 Kb 829
9353 Melanoma.jpg admin 15 Feb, 2018 23:20 26.81 Kb 932
9352 Melanoma 25X.pdf PDF 2018 admin 15 Feb, 2018 23:20 203.28 Kb 636
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