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Vitamin D prevents and treats cancer in many ways – May 2021

Newly-identified Pathways Relating Vitamin D to Carcinogenesis: A Review

In Vivo May 2021, 35 (3) 1345-1354; DOI: https://doi.org/10.21873/invivo.12387


Cancer category starts with the following

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

The review on this page does not appear to mention the Vitamin D Receptor. which is very important in many Cancers

 Download the PDF from VitaminDWiki

Background: The epidemiological relationship between vitamin D levels and cancer has been thoroughly investigated. Published data from large studies appear to corroborate a significant relationship between higher serum vitamin D concentrations and improved survival. Mechanistic reviews on commonly-studied cancers – including breast cancer, colon cancer and melanoma – focus predominantly on data from older studies. In outlining avenues for future research, we believe there is utility in summarizing novel findings introduced to the literature.

Materials and Methods: In this narrative review, we used MEDLINE, PUBMED and Cochrane databases to identify mechanistic studies published from January 1, 2015 onwards exploring this topic.

Results: Twenty-five mechanistic studies were included in this review. It was found that vitamin D plays a critical role in both

  • direct
    • tumor gene expression, proliferation, invasiveness, sensitivity to chemotherapy etc. and
  • indirect
    • effects on the tumor microenvironment and immunomodulation)

tumor suppression mechanisms.

Conclusion: These newly-identified pathways warrant further research, with the hopes that we may understand how and when vitamin D supplementation can be integrated into precision medicine therapeutics for cancers of the breast, colon and skin. Cancer care providers should consider recommendations to screen for vitamin D deficiency in this population.

Created by admin. Last Modification: Wednesday June 16, 2021 22:05:13 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
15532 Cancer prevent and treat.jpg admin 29 Apr, 2021 151.27 Kb 581
15531 Direct and indirect ways Vitamin D stops cancer.pdf admin 29 Apr, 2021 1.62 Mb 274