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2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022


Is early-onset cancer an emerging global epidemic? Current evidence and future implications

Nature Reviews Clinical Oncology volume 19, pages 656–673 (2022)

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Over the past several decades, the incidence of early-onset cancers, often defined as cancers diagnosed in adults <50 years of age, in the

breast, colorectum, Endometrium, oesophagus, extrahepatic bile duct, gallbladder, head and neck, kidney, liver, bone marrow, pancreas, prostate, stomach and thyroid

has increased in multiple countries. Increased use of screening programmes has contributed to this phenomenon to a certain extent, although a genuine increase in the incidence of early-onset forms of several cancer types also seems to have emerged. Evidence suggests an aetiological role of risk factor exposures in early life and young adulthood. Since the mid-20th century, substantial multigenerational changes in the exposome have occurred (including changes in diet, lifestyle, obesity, environment and the microbiome, all of which might interact with genomic and/or genetic susceptibilities). However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies. Raising awareness among both the public and health-care professionals will also be critical. In this Review, we describe changes in the incidence of early-onset cancers globally and suggest measures that are likely to reduce the burden of cancers and other chronic non-communicable diseases.
 Download the PDF from VitaminDWiki

Note: Doubling in 20 years (4% per year) for those aged 20-50

Key points
  • The incidence of cancers of various organs diagnosed in adults ≤50 years of age has been rising in many parts of the world since the 1990s.
  • Evidence suggests an aetiological role for risk factor exposures in early life and young adulthood, although specific effects of individual exposures remain largely unknown.
  • The early life exposome (including, among other factors, diet, lifestyle, obesity, environmental exposures and the microbiome) has changed substantially, with variable trends observed around the world since the mid-20th century.
  • The early-onset cancer epidemic might be one manifestation of increasing trends in the development of many chronic diseases in young and future generations.
  • Prospective cohort studies using electronic health records and/or early-life biospecimen collection would enable the detailed investigation of early-life factors in relation to many future health outcomes, including cancer.
  • Raising awareness of the early-onset cancer epidemic and improving the early-life environment should be our immediate goals: these are likely to reduce the burden of both early-onset and later-onset cancers.

VitaminDWiki candidate reasons include Decreased Vitamin D & Decreased VDR


VitaminDWiki - Cancer category includes Breast, Colon, Liver, Pancreatic, Prostate, and Thyroid


Cancers get less Vitamin D when there is a poor Vitamin D Receptor


Vitamin D Receptor pages in VitaminDWiki with CANCER in title (79 as of Oct 2022)

VDR with Cancer


VitaminDWiki Cancer- Other category with HEAD in title (4 as of Oct 2022)

This list is automatically updated

Items found: 5

VitaminDWiki Cancer- Other category with GASTRIC in title (4 as of Oct 2022)

This list is automatically updated

Items found: 5




Created by admin. Last Modification: Monday October 17, 2022 16:32:14 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
18470 Cancer under 50.jpg admin 23 Sep, 2022 55.09 Kb 198
18469 Cancer before 50.pdf admin 23 Sep, 2022 505.29 Kb 358