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Far fewer Pancreatic Cancer deaths at stage III and IV with more than 20 ng vitamin D – Sept 2013

Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma.

J Transl Med. 2013 Sep 8;11(1):206.
Cho M, Peddi PF, Ding K, Chen L, Thomas D, Wang J, Lockhart AC, Tan B, Wang-Gillam A.

BACKGROUND:The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of vitamin D deficiency in association with ongoing and varying degrees of malabsorption. However, little is known about the correlation between vitamin D status and prognosis in these patients.

METHODS: We conducted a retrospective review of vitamin D status in patients with pancreatic adenocarcinoma who were treated at Siteman Cancer Center. Patients' demographic information, clinical staging at the time of vitamin D assessment, vitamin D levels, and survival data were collected. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D (25[OH]D) level of less than 20 ng/mL, and vitamin D insufficiency was defined as a 25(OH)D level of between 20 ng/mL and 30 ng/mL.

RESULTS: Between December 2007 and June 2011, 178 patients with pancreatic adenocarcinoma had their vitamin D levels checked at the time of initial visit at this center. Of these 178 patients, 87 (49%) had vitamin D deficiency, and 44 (25%) had vitamin D insufficiency. The median 25(OH)D level was significantly lower among nonwhite patients and among patients with stage I and II disease. A 25(OH)D level of less than 20 ng/mL was found to be associated with poor prognosis (p = 0.0019) in patients with stage III and IV disease.

CONCLUSIONS: Vitamin D insufficiency and deficiency were prevalent among patients with pancreatic adenocarcinoma.
The vitamin D level appears to be prognostic for patients with advanced pancreatic adenocarcinoma, and its effects should be further examined in a prospective study.

PMID: 24011168
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derived from Grassroots 2013

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Attached files

ID Name Comment Uploaded Size Downloads
2980 Pancreatic Cancer III IV helped; by vitamin D.jpg admin 10 Sep, 2013 17:11 41.64 Kb 1961
2979 39-Pancreatic adenocarcinoma vit D Cho.pdf PDF 2013 admin 10 Sep, 2013 17:11 356.01 Kb 934
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