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Breast Cancer risk - meta-analysis of 50 studies - Dec 2019


4X less risk of Breast Cancer if 60 ng of Vitamin D - Dec 2019

Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
Aging (Albany NY). 2019 Dec 31; 11(24): 12708–12732. doi: 10.18632/aging.102597
Dingli Song,1,2,* Yujiao Deng,1,2,* Kang Liu,3,* Linghui Zhou,1,2 Na Li,1,2 Yi Zheng,2 Qian Hao,2 Si Yang,2 Ying Wu,2 Zhen Zhai,2 Hongtao Li, corresponding author 4 and Zhijun Dai corresponding author1,2

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Epidemiological studies have indicated that blood vitamin D levels are linked to cancer. Here we conducted a dose–response meta-analysis based on published observational studies to evaluate the association of vitamin D intake and blood vitamin D levels with breast cancer susceptibility. PubMed, EMBASE, and Web of Science databases were searched up to January 2019. The pooled odds ratio (OR) and 95% confidence intervals (CIs) were extracted to estimate the risk. We identified 70 relevant studies on blood vitamin D levels (50 studies) and vitamin D intake (20 studies), respectively. Linear and nonlinear trend analyses were performed and showed that an increase in blood vitamin D levels by 5 nmol/l was associated with a 6% decrease in breast cancer risk (OR = 0.94, 95% CI = 0.93–0.96). Similar results were obtained for premenopausal (OR = 0.96, 95% CI = 0.93–0.99) and postmenopausal women (OR = 0.96, 95% CI = 0.94–0.98). The pooled OR of breast cancer risk for a 400IU/day increase in vitamin D intake was 0.97 (95% CI = 0.92–1.02). In conclusion, we found that breast cancer risk was inversely related to blood vitamin D levels; however, no significant association was observed in vitamin D intake.
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19375 Meta BC trimmed.jpg admin 25 Mar, 2023 59.95 Kb 232
19374 Breast Cancer dose response meta-analysis_CompressPdf.pdf admin 25 Mar, 2023 883.64 Kb 204