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People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023

Association between the Serum Vitamin D Concentration and All-Cause and Cancer-Specific Mortality in Individuals with Cancer

Nutrition and Cancer Nov 2023 https://doi.org/10.1080/01635581.2023.2279233
PDF is behind a paywall, but it does look good
Yu Bai,Yong-qing Wen &Xu Ma

We aimed to explore the association between the serum 25-hydroxyvitamin D concentration and all-cause and cancer-specific mortality in 2,463 adult patients with cancer from the National Health and Nutrition Examination Survey 2007–2018. We linked mortality data from the survey to the National Death Index records up to December 31, 2019. During a median follow-up period of 70 months, 567 patients died, of whom 194 died due to cancer. Multivariate adjustment was performed for demographic characteristics, lifestyle, dietary factors, 25-hydroxyvitamin D testing period, and cancer site. Higher serum 25-hydroxyvitamin D concentrations up to 75 nmol/L significantly reduced the risk of all-cause and cancer-specific mortality. When 25-hydroxyvitamin D quartiles were compared, the multivariable-adjusted hazard ratios were 0.59 (95% confidence interval: 0.42, 0.84) for all-cause mortality (P for trend <0.001) and 0.48 (95% confidence interval: 0.29, 0.79) for cancer-specific mortality (P for trend = 0.037) in quartile 3 (79.3–99.2 nmol/L). A threshold of 75 nmol/L for serum 25-hydroxyvitamin D may represent an intervention target to reduce mortalities in patients with cancer, and maintaining 25(OH)D concentrations within range (79.3–99.2 nmol/L) is beneficial for reducing all-cause and cancer-specific mortality.

24 References
  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA cancer J Clin. 2021;71(3):209–49. doi: 10.3322/caac.21660. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  2. Siegel RL, Miller KD, Wagle NS, Jemal A. cancer statistics, 2023. CA cancer J Clin. 2023;73(1):17–48. doi: 10.3322/caac.21763. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  3. Lucock M, Jones P, Martin C, Yates Z, Veysey M, Furst J, Beckett E. Photobiology of vitamins. Nutr Rev. 2018;76(7):512–25. doi: 10.1093/nutrit/nuy013. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  4. Delrue C, Speeckaert MM. Vitamin D and vitamin D-binding protein in health and disease. Int J Mol Sci. 2023;24(5):4642. doi: 10.3390/ijms24054642. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  5. Jeon SM, Shin EA. Exploring vitamin D metabolism and function in cancer. Exp Mol Med. 2018;50(4):1–14. doi: 10.1038/s12276-018-0038-9. [Crossref] [Web of Science ®], [Google Scholar]
  6. Carlberg C, Velleuer E. Vitamin D and the risk for cancer: a molecular analysis. Biochem Pharmacol. 2022;196:114735. doi: 10.1016/j.bcp.2021.114735. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  7. Kantor ED, Rehm CD, Du M, White E, Giovannucci EL. Trends in dietary supplement use among US adults from 1999-2012. JAMA. 2016;316(14):1464–74. doi: 10.1001/jama.2016.14403. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  8. Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D’Agostino D, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med. 2019;380(1):33–44. doi: 10.1056/NEJMoa1809944. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  9. Kwak JH, Paik JK. Vitamin D status and gastric cancer: a cross-sectional study in Koreans. Nutrients. 2020;12(7):2004. doi: 10.3390/nu12072004. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  10. Zhang Y, Fang F, Tang J, Jia L, Feng Y, Xu P, Faramand A. Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ. 2019;366:l4673. doi: 10.1136/bmj.l4673. [Crossref] [PubMed], [Google Scholar]
  11. Arayici ME, Basbinar Y, Ellidokuz H. Vitamin D intake, serum 25-hydroxyvitamin-D (25(OH)D) levels, and cancer risk: a comprehensive meta-meta-analysis including meta-analyses of randomized controlled trials and observational epidemiological studies. Nutrients. 2023;15(12):2722. doi:10.3390/nu15122722. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  12. Centers for Disease Control and Prevention. National Health and Nutritional Examination Survey: methods and analytic guidelines. Washington(DC): Office of the Associate Director for Communication, Digital Media Branch, Division of Public Affairs; 2022. [accessed 2023 Mar 20]. https://wwwn.cdc.gov/nchs/nhanes/AnalyticGuidelines.aspx. [Google Scholar]
  13. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30. doi: 10.1210/jc.2011-0385. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  14. de la Puente Yagüe M, Collado Yurrita L, Ciudad Cabañas MJ, Cuadrado Cenzual MA. Role of vitamin D in athletes and their performance: current concepts and new trends. Nutrients. 2020;12(2):579. doi: 10.3390/nu12020579. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  15. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5(7):2502–21. doi: 10.3390/nu5072502. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  16. Casseb GAS, Kaster MP, Rodrigues ALS. Potential role of vitamin D for the management of depression and anxiety. CNS Drugs. 2019;33(7):619–37. doi: 10.1007/s40263-019-00640-4. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  17. Pilz S, Verheyen N, Grübler MR, Tomaschitz A, März W. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol. 2016;13(7):404–17. doi: 10.1038/nrcardio.2016.73. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  18. Chen QY, Kim S, Lee B, Jeong G, Lee DH, Keum N, Manson JE, Giovannucci EL. Post-diagnosis vitamin D supplement use and survival among cancer patients: a meta-analysis. Nutrients. 2022;14(16):3418. doi:10.3390/nu14163418. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  19. Fan X, Wang J, Song M, Giovannucci EL, Ma H, Jin G, Hu Z, Shen H, Hang D. Vitamin D status and risk of all-cause and cause-specific mortality in a large cohort: results from the UK Biobank. J Clin Endocrinol Metab. 2020;105(10):e3606–e3619. doi: 10.1210/clinem/dgaa432. [Crossref] [Web of Science ®], [Google Scholar]
  20. Sutherland JP, Zhou A, Hyppönen E. Vitamin D deficiency increases mortality risk in the UK Biobank: a nonlinear Mendelian randomization study. Ann Intern Med. 2022;175(11):1552–9. doi: 10.7326/M21-3324. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  21. Wang J, Fan J, Yang Y, Moazzen S, Chen D, Sun L, He F, Li Y. Vitamin D status and risk of all-cause and cause-specific mortality in osteoarthritis patients: results from NHANES III and NHANES 2001-2018. Nutrients. 2022;14(21):4629. doi: 10.3390/nu14214629. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  22. Maalmi H, Ordóñez-Mena JM, Schöttker B, Brenner H. Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: systematic review and meta-analysis of prospective cohort studies. Eur J Cancer. 2014;50(8):1510–21. doi:10.1016/j.ejca.2014.02.006. [Crossref] [PubMed] [Web of Science ®], [Google Scholar]
  23. Wu G, Xue M, Zhao Y, Han Y, Zhang S, Zhang J, Li C, Xu J. Low circulating 25-hydroxyvitamin D level is associated with increased colorectal cancer mortality: a systematic review and dose-response meta-analysis. Biosci Rep. 2020;40(7):BSR20201008. doi:10.1042/BSR20201008. [Crossref] [PubMed], [Google Scholar]

34+ VitaminDWiki Mortality pages have CANCER in the title

This list is automatically updated

Items found: 36
Title Modified
3 Cancers have higher mortality if high PTH (which can be lowered by Vitamin D) - Aug 2024 15 Aug, 2024
Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 01 May, 2024
People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 23 Nov, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 03 Jul, 2022
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 15 Oct, 2021
Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 17 Aug, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 31 Dec, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 08 Nov, 2019
Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 10 Sep, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 07 May, 2019
Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 13 Apr, 2019
Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 26 Nov, 2018
Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival 10 Sep, 2018
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 13 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 15 Jun, 2016
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 17 Jun, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Vitamin D and Cancer Mortality – review Jan 2013 17 Sep, 2013
Mortality and Cancer varies with latitude in France too – 2010 26 Oct, 2012
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Lack of solar UVB in US is associated with some Cancers - 2006 28 Dec, 2011
Solar radiation, vitamin D and cancer incidence and mortality in Norway 13 Apr, 2010

People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023        
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