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Newly diagnosed Children with Cancer have low vitamin D, especially if black - May 2022


Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex

Cancers 2022,14, 2378. https:// doi.org/10.3390/cancers14102378
Michell Fullmer 1, Annelise Su 2©, Steven Bachrach 3, Jobayer Hossain 4 and Heidi H. Kecskemethy 5'*


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Simple Summary: In this cross-sectional retrospective review of serum 25(OH)D levels in 544 children, children newly diagnosed with cancer (n = 136) had significantly lower 25(OH)D levels at diagnosis than their age-, sex-, and race-matched peers without cancer from the same geographic region of the US (n = 408). Significant differences were evident: older children exhibited lower 25(OH)D levels, children of color displayed higher levels of insufficiency, and black children were most deficient.

Children with cancer have a greater risk for vitamin D concerns because of compromised health before diagnosis, the disease itself, and treatments for the cancer. This IRB-approved retrospective, matched case-control study of children with and without cancer included three race categories: black, other, and Caucasian. This is the first study to directly compare serum 25-hydroxy vitamin D (25(OH)D) levels and status in newly diagnosed pediatric cancer patients with age-, sex-, and race-matched cancer-free children from the same geographic region of the US, all of whom are free from other conditions that negatively impact 25(OH)D levels. Univariable and multivariable ordinal logistic regressions were performed. In the 544 children (mean age of 8.5 years, 53% female), there were 136 newly diagnosed children with cancer and 408 matched non-cancer controls. Serum 25(OH)D levels at cancer diagnosis were lower (22.4 ng/mL) than in controls (30.1 ng/mL; p < 0.0001). Differences persisted across race (p < 0.001) and age (p < 0.001), but not sex. Older children exhibited lower 25(OH)D levels. Only 18.4% of the children with cancer had sufficient levels. Black children with cancer had the greatest rate of deficiency (39%). Race differences were evident: children of color (other and black) displayed higher levels of insufficiency; black children were most deficient.
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Conclusions

This paper adds to the increasing evidence that children newly diagnosed with cancer are at greater risk for a compromised vitamin D status, and it underscores the importance of prompt evaluation of 25(OH)D levels when a child is diagnosed with cancer. Because of these findings, and other similar studies, institutions caring for children with cancer are beginning to consider and evaluate the implementation of vitamin D testing at the time of diagnosis as a part of standard care 39. Within our own pediatric health care system, we have observed varying practices regarding vitamin D testing at the time of cancer diagnosis in children. The implementation of a care pathway, including serum 25(OH)D testing upon a cancer diagnosis, will allow for the prompt identification of patients who require a correction of vitamin D deficiency or insufficiency to improve patient health and response to treatment, and to help prevent the known bone health problems that children with cancer often develop.
This study shows that children with cancer of all races demonstrated significantly lower 25(OH)D levels at diagnosis than their age-, sex-, and race-matched non-oncology peers. Risk factors for compromised 25(OH)D status were older age and cancer diagnosis. Patients of color exhibited a greater incidence of vitamin D insufficiency, and black children had the greatest levels of deficiency. The significance of this finding relative to the development or progression of cancer is unclear, but worthy of further investigation.


VitaminDWiki Infant-Child pages with CANCER in title (11 as of June 2022)

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Items found: 12

VitaminDWiki Skin-Dark pages with CANCER in title (30 as of June 2022)

This list is automatically updated

Items found: 30
Title Modified
Newly diagnosed Children with Cancer have low vitamin D, especially if black - May 2022 16 Jun, 2022
Cancer continues to be more deadly for Blacks than Whites (hint – low Vitamin D) – May 2022 30 May, 2022
Cancer of breast is highest in dark-skinned women (low Vitamin D: dark skin and obese) - Feb 2022 12 Feb, 2022
Cancers and Vitamin D Receptors, including change with race – Feb 2021 24 Oct, 2021
Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020 19 Feb, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies 14 Jun, 2019
Blacks are more obese, have lower Vitamin D, and have more Cancer etc. than whites – Feb 2018 03 May, 2018
Hypothesis: Blacks get more cancer than whites due to lower levels of vitamin D – June 2012 03 May, 2018
Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017 20 Nov, 2017
Breast cancer in blacks – 5X increased risk of triple negative if low vitamin D – Oct 2017 01 Nov, 2017
Breast cancer worse for black women – Sept 2011 19 Aug, 2017
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 06 Mar, 2017
Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017 28 Dec, 2016
Head and Neck Cancer associated with low vitamin D, especially with blacks - April 2012 17 Nov, 2016
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 14 Nov, 2016
Higher rate of prostate cancer in AA may decrease if take vitamin D – July 2016 07 Jul, 2016
Prostate Cancer incidence and death 2X more often among black men (vitamin D not mentioned) - July 2015 30 Jul, 2015
Kidney Cancer differences with skin color probably due to vitamin D differences – May 2015 25 May, 2015
Tanning potential predicts risk of Prostate Cancer in Blacks – Nov 2014 02 Jan, 2015
Cancer patients at high risk of vitamin D deficiency were not tested as often (paradoxically) – July 2014 12 Aug, 2014
Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014 21 May, 2014
Barefoot on mega doses of vitamin D and his book on Cancer 10 Apr, 2014
Hypothesis - Dark skin evolved to avoid skin cancer - Feb 2014 02 Mar, 2014
Breast cancer more deadly for blacks than whites 13 Feb, 2014
Skin cancer risk and vitamin D from sun both decrease with darker skin – March 2013 10 Nov, 2013
Hypothesis: Vitamin D is related to breast cancer racial disparities in the US - Sept 2012 08 Jul, 2013
Genes may account for some of AA Breast Cancer – April 2012 08 Jul, 2013
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Low vitamin D in blacks increases colorectal cancer deaths 40 percent – Cancer Oct 2010 23 Oct, 2010


Created by admin. Last Modification: Thursday June 16, 2022 00:41:45 GMT-0000 by admin. (Version 6)

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17883 Children Cancer.jpg admin 16 Jun, 2022 00:39 22.39 Kb 33
17882 cancers-14-02378_CompressPdf.pdf PDF 2022 admin 16 Jun, 2022 00:39 190.35 Kb 14
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