Longitudinal, observational study on associations between postoperative nutritional vitamin D supplementation and clinical outcomes in esophageal cancer patients undergoing esophagectomy.
Sci Rep. 2016 Dec 13;6:38962. doi: 10.1038/srep38962.
Wang L1, Wang C1, Wang J1, Huang X1, Cheng Y1.
1Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
200-400 IU of Vitamin D appears to help at lot
See also VitaminDWiki
- Overview Cancer and vitamin D includes the following charts
Green patients appeared to take 200-400 IU of vitamin D
The study recorded dose size and duration but failed to include that data in the published study
Study also failed to measure Vitamin D levels of each group.
Vitamin D can exert anticancer effect beyond bone and calcium metabolism. We aimed to investigate whether postoperative vitamin D supplementation affects quality of life (QOL) and survival in esophageal cancer (EC) patients. We utilized the widely used EORTC QLQ-C30 and QLQ-OES18 to assess QOL at EC diagnosis and 24 months after surgery. Generalized estimating equations (GEEs) were used to analysis the association of vitamin D supplement use with QOL. Kaplan-Meier method and Cox regression model were used to evaluate the prognostic value of vitamin D supplementation. The notably improved QOL were found among vitamin D supplementation users compared with non-users (p < 0.05). Kaplan-Meier analysis revealed that vitamin D supplement use was significantly associated with improved disease-free survival (DFS) (p = 0.030), but not related to overall survival (OS) (p = 0.303). The multivariable analysis further demonstrated vitamin D supplement use as an independent prognostic factor for DFS (p = 0.040; HR 0.610; 95% CI 0.381-0.978).
In conclusion, these results showed that vitamin D supplement use could serve as a promising intervention to enhancing QOL and prolonging DFS in EC.
PMID: 27958342 DOI: 10.1038/srep38962
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. . "only 49 patients (16.2%) self-reported to regularly receive vitamin D supplement. The dosage of it was 200–400 IU daily, which was suggested by clinician and also recommended by Chinese Nutrition Society and World Health Organization. "
" In our study, EC patients who were supplemented with vitamin D had
- higher scores of physical functioning, social functioning and global health as well as
- lower scores of fatigue and appetite loss
via a 24-month follow-up compared with non-users. It suggested that vitamin D users were more likely to maintain
physical function, have more energy and better appetite, feel less faintness as well as enjoy life. These findings
were consistent with previous study20, which reported that stage II colorectal cancer patients who supplemented
vitamin D tended to have better QOL. Another cross-sectional study indicated that vitamin D deficiency was
quite common as well as associated with fatigue and poor physical and functional well-being in advanced cancer
patients19. Therefore, it pointed to vitamin D supplementation as a potential therapy to improve cancer patients’
QOL. Although vitamin D status is unknown in the current study, vitamin D supplement use did show a significant
relationship with QOL."