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Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019

Effects of Vitamin D and Omega-3 Fatty Acids Co-Supplementation on Inflammatory Factors and Tumor Marker CEA in Colorectal Cancer Patients Undergoing Chemotherapy: A Randomized, Double-Blind, Placebo-Controlled Clinical trial

Nutrition and Cancer https://doi.org/10.1080/01635581.2019.1659380
Fatemeh Haidari, Behnaz Abiri, Masood Iravani, Kambiz Ahmadi-Angali & Mohammadreza Vafa


8 weeks of Omega-3 daily plus 50,000 IU vitamin D weekly
The good results would have been great if had
Used more Vitamin D (perhaps a loading dose)
Used a gut-friendly form of vitamin D
Participants take the Vitamin D with the largest meal of the day
Started the Vitamin D and Omega-3 before the surgery
Dose sizes which varied with weight (not one-size-fits-all)


Omega-3 and Cancer

Vitamin D and Cancer

Vitamin D Receptor can limit the amount of Vitamin D actually getting to tissue

Chemo works better with when there is a good level of Vitamin D

Cancer - Colon category starts with the following

 Download the PDF from Sci-Hub via VitaminDWiki

Objectives: This study aimed to investigate the effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory factors and tumor marker CEA in colorectal cancer patients undergoing chemotherapy.

Methods: In this study, 81 patients with stage ӀӀ or ӀӀӀ colorectal cancer were randomly assigned into four groups: (1) control: receiving a vitamin D placebo, weekly + two omega-3 fatty acid placebo capsules, daily; (2) omega-3 fatty acid, receiving two omega-3 fatty acid capsules (each capsule containing 330 mg of omega-3 fatty acids), daily + a vitamin D placebo, weekly; (3) vitamin D, receiving a 50,000 IU vitamin D soft gel, weekly + two omega-3 fatty acid placebo capsules, daily; (4) co-supplementation, receiving a 50,000 IU vitamin D soft gel, weekly + two omega-3 fatty acids capsules, for 8 weeks. Before and after the intervention, serum levels of 25(OH)D, TNF-α, IL-1β, IL-6, IL-8, NF-kB activity, and tumor marker CEA, were measured.

Results: After 8 weeks of intervention, patients who received combined vitamin D and omega-3 fatty acids supplements compared with omega-3, vitamin D, and placebo had significantly decreased TNF-α, and IL-1β (P < .05). In addition, serum levels of TNF-α, IL-1β, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. NF-kB activity was decreased significantly in vitamin D and co-supplementation groups, compared with baseline. Regarding CEA, there was no significant difference between the four groups at the end of intervention (P > .05).

Conclusion: Results show that co-supplementation of vitamin D and omega-3 fatty acids co-supplementation, in colorectal cancer patients have beneficial impacts on inflammation and tumor marker CEA.

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Created by admin. Last Modification: Sunday July 25, 2021 11:02:32 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
12593 Omega-3 plus Vit D.jpg admin 06 Sep, 2019 74.46 Kb 714
12592 Omega-3plus Vit D sci-hub.pdf admin 06 Sep, 2019 603.87 Kb 642