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Pancreatic Cancer risk increased 24 percent for every 100 mg less of Magnesium intake – Dec 2015

Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study.

Br J Cancer. 2015 Dec 1;113(11):1615-21. doi: 10.1038/bjc.2015.382. Epub 2015 Nov 10.
Dibaba D1, Xun P1, Yokota K2, White E3,4, He K1.

VitaminDWiki

Cancer- Pancreatic


Magnesium and Vitamin D contains the following summary

203 items in category, see also

Pages listed in BOTH the categories Magnesium and Diabetes (associated with Pancreas)

Note: The people supplementing with Magnesium ALSO supplemented with Selenium, Calcium and Omega-3

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Note: The benefits of Magnesium appear to have only been seen in those taking supplements

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 Download the PDF from VitaminDWiki

BACKGROUND:
Studies document that magnesium is inversely associated with the risk of diabetes, which is a risk factor of pancreatic cancer. However, studies on the direct association of magnesium with pancreatic cancer are few and findings are inconclusive. In this study, we aimed to investigate the longitudinal association between magnesium intake and pancreatic cancer incidence in a large prospective cohort study.

METHOD:
A cohort of 66,806 men and women aged 50-76 years at baseline who participated in the VITamins And Lifestyle (VITAL) study was followed from 2000 to 2008. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of pancreatic cancer incidence by magnesium intake categories.

RESULT:
During an average of 6.8-year follow-up, 151 participants developed pancreatic cancer. Compared with those who met the recommended dietary allowance (RDA) for magnesium intake, the multivariable-adjusted HRs (95% CIs) for pancreatic cancer were 1.42 (0.91, 2.21) for those with magnesium intake in the range of 75-99% RDA and 1.76 (1.04, 2.96) for those with magnesium intake <75% RDA. Every 100 mg per day decrement in magnesium intake was associated with a 24% increase in the incidence of pancreatic cancer (HR: 1.24; 95% CI: 1.02, 1.50; P(trend)=0.03). The observed inverse associations appeared not to be appreciably modified by age, gender, body mass index, and non-steroidal anti-inflammatory drug use but appeared to be limited to those taking magnesium supplementation (from multivitamins or individual supplement).

CONCLUSIONS:
Findings from this prospective cohort study indicate that magnesium intake may be beneficial in terms of primary prevention of pancreatic cancer.

Created by admin. Last Modification: Tuesday August 7, 2018 15:15:57 UTC by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
10316 PC non supplement users.jpg admin 07 Aug, 2018 14:52 107.18 Kb 18
10315 Pancreatic Cancer supplements.jpg admin 07 Aug, 2018 14:52 70.41 Kb 15
10314 Magnesium intake and incidence of pancreatic cancer.pdf admin 07 Aug, 2018 14:51 192.89 Kb 5
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