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Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024

Association of serum 25-hydroxy-vitamin D concentration and risk of mortality in cancer survivors in the United States

BMC Cancer. 2024 Apr 30;24(1):545. doi: 10.1186/s12885-024-12304-8. PDF is behind paywall
Xiaofei Mo # 1 2, Chen He # 3 4, Fengfeng Han 3 4, Hui Yan 3 4, Xueqin Chen 3 4, Yuetao Wang 3 4, Mingge Zhou 5 6

Purpose: Cancer survivors have a high risk of mortality, and vitamin D (VD) is associated with the risk of mortality. This study is aim to examine the impact of VD on mortality in cancer survivors.

Methods: A prospective study was conducted using data from the National Health and Nutrition Examination Survey. Participants were obtained information on their baseline characteristics, dietary habits, comorbidities, lifestyle, and serum 25-hydroxy VD [25(OH)D] concentrations. The weighted Cox proportional hazard and competing risk regression models were used to estimate the hazard ratio and 95% confidence intervals (HR, 95% CI) of mortality for different serum 25(OH)D concentrations. Restricted cubic spline (RCS) curves were utilized to illustrate the dose-response relationship between serum 25(OH)D concentrations and mortality.

Results: The study encompassed 2,495 participants with cancer diagnoses. Multivariate models indicated that, compared to serum 25(OH)D concentrations below 58.5 nmol/L, concentrations exceeding 81.6 nmol/L were associated with reduced HRs for

  • all-cause mortality (HR = 0.70; 95% CI: 0.56-0.87),
  • cardiovascular mortality (HR = 0.53; 95% CI: 0.32-0.86), and
  • cancer-specific mortality (HR = 0.66; 95% CI: 0.45-0.99).

RCS curves revealed "L-shaped" associations between serum 25(OH)D concentration and both all-cause and cancer-specific mortality, with threshold effects at 87.9 nmol/L and 84.6 nmol/L, respectively. Conversely, the relationship between serum 25(OH)D concentration and cardiovascular mortality exhibited a more linear pattern, with a threshold at 88.7 nmol/L. Subgroup analyses highlighted a gender-specific interaction that elevated serum 25(OH)D concentrations were significantly more protective against mortality in males than in females, especially regarding cancer-specific mortality (P-interaction = 0.009).

Conclusion: Elevated serum 25(OH)D concentrations were correlated with decreased risks of all-cause, cardiovascular, and cancer-specific mortality in cancer survivors, with benefit thresholds at 87.9, 88.7, and 84.6 nmol/L, respectively. These findings suggested that cancer survivors might benefit from higher vitamin D recommendations than the general population.

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VitaminDWiki – Mortality category contains:

People die sooner if they have low vitamin D
Mortality is.gd/VitaminDMortality
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There are 314 articles in Mortality category

VitaminDWiki - 26 studies are in both of the categories Mortality and Cardiovascular

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37+ VitaminDWiki Mortality pages have CANCER in the title

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Items found: 37
Title Modified
Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 01 May, 2024
People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 23 Nov, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 01 May, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 03 Jul, 2022
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 15 Oct, 2021
Cancer mortality not reduced by small vitamin D doses - Sept 2021 21 Sep, 2021
Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 17 Aug, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 31 Dec, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 08 Nov, 2019
Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 10 Sep, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 07 May, 2019
Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 13 Apr, 2019
Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 26 Nov, 2018
Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival 10 Sep, 2018
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 13 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 15 Jun, 2016
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 17 Jun, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Vitamin D and Cancer Mortality – review Jan 2013 17 Sep, 2013
Mortality and Cancer varies with latitude in France too – 2010 26 Oct, 2012
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Lack of solar UVB in US is associated with some Cancers - 2006 28 Dec, 2011
Solar radiation, vitamin D and cancer incidence and mortality in Norway 13 Apr, 2010

Vitamin D taken monthly results in >36 ng - for just $5/year