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Vitamin D does not treat colon cancer (when you only use 1,000 IU) – RCT April 2019

No Evidence for Posttreatment Effects of Vitamin D and Calcium Supplementation on Risk of Colorectal Adenomas in a Randomized Trial

Cancer Prevention Research DOI: 10.1158/1940-6207.CAPR-19-0023
Audrey H. Calderwood, John A. Baron, Leila A. Mott, Dennis J. Ahnen, Roberd M. Bostick, Jane C. Figueiredo, Michael N. Passarelli, Judy R. Rees, Douglas J. Robertson and Elizabeth L. Barry


That they used only a paltry 1,000 IU was hidden deep inside of the PDF

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Vitamin D and calcium supplementation are postulated to have chemopreventive effects against colorectal neoplasia, yet in our previously reported randomized trial, there was no overall efficacy of calcium and/or vitamin D3 against colorectal adenoma recurrence. It is possible vitamin D3 and calcium chemopreventive effects are not detectable until beyond the 3- to 5-year follow-up captured in that trial. Accordingly, we explored possible vitamin D and calcium effects on posttreatment (observational) adenoma occurrence. In this secondary analysis of the observational follow-up phase of the Vitamin D/Calcium Polyp Prevention Study, participants who completed the treatment phase were invited to be followed for one additional surveillance colonoscopy cycle. We evaluated adenoma occurrence risk at surveillance colonoscopy, with a mean of 55 ± 15 months after treatment follow-up, according to randomized treatment with vitamin D versus no vitamin D, calcium versus no calcium, and calcium plus vitamin D versus calcium alone. Secondary outcomes included advanced and multiple adenomas. Among the 1,121 participants with observational follow-up, the relative risk (95% confidence interval, CI) of any adenoma was 1.04 (0.93–1.17) for vitamin D versus no vitamin D; 0.95 (0.84–1.08) for calcium versus no calcium; 1.07 (0.91–1.25) for calcium plus vitamin D versus calcium; and 0.96 (0.81–1.15) for calcium plus vitamin D versus neither. Risks of advanced or multiple adenomas also did not differ by treatment. Our results do not support an association between supplemental calcium and/or vitamin D3 for 3 to 5 years and risk of recurrent colorectal adenoma at an average of 4.6 years after treatment.

Created by admin. Last Modification: Saturday April 13, 2019 08:30:22 GMT-0000 by admin. (Version 1)

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11753 10.1158@1940-6207.CAPR-19-0023.pdf PDF 2019 admin 13 Apr, 2019 08:31 1.22 Mb 73
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