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Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018

Circulating vitamin D level and mortality in prostate cancer patients: a dose-response meta-analysis

Endocrine Connections DOI: https://doi.org/10.1530/EC-18-0283
Zhenyu Song 1 , Qiuming Yao 2 , Zhiyuan Zhuo 3 , Zhe Ma 4 and Gang Chen 5 chgan305 at 163.com

prostate cancer mortality


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Background: Previous studies investigating the association of circulating 25-hydroxyvitamin D level with prognosis of prostate cancer yielded controversial results. We conducted a dose-response meta-analysis to elucidate the relationship.

Methods: PubMed and Embase were searched for eligible studies up to July 15, 2018. We performed a dose-response meta-analysis using random-effect model to calculate the summary hazard ratio (HR) and 95% confidence interval (CI) of mortality in patients with prostate cancer.

Results: Seven eligible cohort studies with 7,808 participants were included. The results indicated that higher vitamin D level could reduce the risk of death among prostate cancer patients. The summary HR of prostate cancer-specific mortality correlated with an increment of every 20 nmol/L in circulating vitamin D level was 0.91, with 95% CI 0.87-0.97, P=0.002. The HR for all-cause mortality with the increase of 20 nmol/L vitamin D was 0.91 (95% CI: 0.84-0.98, P=0.01). Sensitivity analysis suggested the pooled HRs were stable and not obviously changed by any single study. No evidence of publications bias was observed.

Conclusion: This meta-analysis suggested that higher 25-hydroxyvitamin D level was associated with a reduction of mortality in prostate cancer patients and vitamin D is an important protective factor in the progression and prognosis of prostate cancer.

No association of PSA with Vitamin D - Meta-analysis Dec 2018

The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials

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