Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue
Nutrients 2019, 11(3), 642; https://doi.org/10.3390/nu11030642 (registering DOI)
Araceli Muñoz-Garach 1,2,* , Beatriz García-Fontana 3,4 and Manuel Muñoz-Torres 3,4,5,6,*
VitaminDWiki
Pages listed in BOTH of the categories Diabetes and Intervention
- Type 1 Diabetic inflammation reduced by 50 ng of Vitamin D - Dec 2024
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022
- Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT June 2020
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
- Little Vitamin D benefit if not achieve a good level (T1D in this cases) – Jan 2021
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- Diabetes not helped by increasing Vitamin D levels to 20 ng (proven again) – RCT March 2020
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Diabetes helped by 5,000 IU of Vitamin D – RCT Sept 2019
- 100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT Dec 2019
- Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT July 2019
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Vitamin D fails to prevent Type 2 Diabetes (unaware of 8 proven ways) June 2019
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016
- Diabetes treated by vitamin D when levels exceeded 61 ng – Sept 2015
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Diabetes decreased in aged mice supplemented with vitamin D – April 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Recent Diabetics treated by supplementation which achieved 60 ng of vitamin D – RCT Sept 2014
- Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT March 2014
- Prediabetics 60 percent less likely to become diabetic if given some vitamin D – Jan 2014
- Diabetes prevention RCT kicked off: adding 4,000 IU vitamin D - Oct 2013
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Insulin improvement in obese teens with 4000 IU of vitamin D – RCT Feb 2013
Pages listed in BOTH of the categories Diabetes and Meta-analysis
- Diabetes and Vitamin D meta-analyses - many studies
- T2 Diabetes and associated CVD problems fought by Vitamin D (weekly 50,000 IU) – Sept 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Glycemic control of type 2 diabetes – only Vitamin D had high quality studies – meta-analysis Sept 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis May 2021
- Diabetic Neuropathy 2.8X higher risk if low vitamin D – meta-analysis May 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis April 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Diabetic Foot Ulcer 1.4 to 3.6 X more likely if low vitamin D – several meta-analyses
- Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
- Diabetes treated and prevented by more than 2,000 IU of vitamin D (need more and gut-friendly) - meta-analyses 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Hyperglycemia associated with low vitamin D – type II diabetics and healthy people – meta-analysis Jan 2018
- Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis Sept 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic Retinopathy twice as likely if a T2 Diabetic has low level of vitamin D – meta-analysis March 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Diabetic Retinopathy 27 percent more likely if low vitamin D – meta-analysis May 2016
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Diabetes not prevented by Vitamin D (when you ignore how much vitamin D was taken) – Sept 2015
- Diabetics are 2.7 X more likely to get peripheral neuropathy if low vitamin D – meta-analysis Dec 2014
- Diabetes not prevented or treated if give only modest amount of vitamin D or for short period of time – meta-analysis July 2014
- Type 2 diabetes 1.5X more likely if low vs high vitamin D – meta-analysis Feb 2013
- 4 percent less type 2 diabetes for every 4 ng more vitamin D – meta-analysis May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Diabetes down 13 percent if more than 500 IU of vitamin D – meta-analysis July 2011
Pages listed in BOTH of the categories Diabetes and Calcium
- Vitamin D Roles - more than just help the immune system
- Vitamin D prevents diabetes but Dairy does not appear to help – March 2019
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
Download the PDF from VitaminDWiki
The relationship between vitamin D status, calcium intake and the risk of developing type 2 diabetes (T2D) is a topic of growing interest. One of the most interesting non-skeletal functions of vitamin D is its potential role in glucose homeostasis. This possible association is related to the secretion of insulin by pancreatic beta cells, insulin resistance in different tissues and its influence on systemic inflammation.
However, despite multiple observational studies and several meta-analyses that have shown a positive association between circulating 25-hydroxyvitamin D concentrations and the risk of T2D, no randomized clinical trials supplementing with different doses of vitamin D have confirmed this hypothesis definitively.
An important question is the identification of what 25-hydroxyvitamin D levels are necessary to influence glycemic homeostasis and the risk of developing T2D. These values of vitamin D can be significantly higher than vitamin D levels required for bone health, but the currently available data do not allow us to answer this question adequately. Furthermore, a large number of observational studies show that dairy consumption is linked to a lower risk of T2D, but the components responsible for this relationship are not well established. Therefore, the importance of calcium intake in the risk of developing T2D has not yet been established. Although there is a biological plausibility linking the status of vitamin D and calcium intake with the risk of T2D, well-designed randomized clinical trials are necessary to answer this important question.