Toggle Health Problems and D

Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT Nov 2022

Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial

BMC Psychiatry . 2022 Nov 11;22(1):694. doi: 10.1186/s12888-022-04305-3.
Mina Kaviani 1 , Bahareh Nikooyeh 2 , Farnaz Etesam 3 , Siroos Jahangiri Behnagh 4 , Hamed Mohammadi Kangarani 5 , Mohammad Arefi 5 , Parichehreh Yaghmaei 6 , Tirang R Neyestani 7

Background: Both augmented inflammatory reaction and low vitamin D status are associated with depression but the magnitude of their relationships is unclear. This study was, therefore, conducted to evaluate the effects of vitamin D supplementation on serum 25(OH)D concentration, depression severity and some pro-inflammatory biomarkers in patients with mild to moderate depression.

Methods: An 8-week double-blind randomized clinical trial (RCT) was performed on 56 (18-60 yrs) patients with mild to moderate depression, randomly assigned to intervention (50,000 IU cholecalciferol 2wks-1) and control (placebo) groups. Serum 25(OH)D, intact parathyroid hormone (iPTH), interlukin (IL)-1β, IL-6, high-sensitivity C-reactive protein (hs-CRP) and depression severity (Beck Depression Inventory-II) (BDI-II)) were initially and finally assessed.

Results: At the end point, statistically significant changes were observed only in intervention group as compared with controls including increased 25(OH)D concentration (+ 40.83 ± 28.57 vs. + 5.14 ± 23.44 nmol L-1, P < 0.001) and decreased depression severity (-11.75 ± 6.40 vs. -3.61 ± 10.40, P = 0.003). No significant within- or between group differences were observed in serum IL-1β, IL-6 and hs-CRP concentrations.

Conclusion: Increased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks-1) resulted in a significant decrease in BDI-II scores in patients with mild to moderate depression. However, this effect was independent of the serum concentrations of the studied inflammatory biomarkers.

Trial registration: The clinical trial registration code was obtained from the Iranian Registry of Clinical Trials (date of registration: 17/09/2018, registration number: IRCT20170926036425N1) and ClinicalTrials.gov (date of registration: 04/12/2018, registration number: NCT03766074).
No such attachment on this page

Intervention of Vitamin D for Depression

Meta-analyses of Vitamin D and Depression

VitaminDWiki - Depression category contains

Some recent publications

Many other health problems fought by 50,000 IU weekly or biweekly

ADHD,  Anxiety,  Asthma,  Autism,  Back Pain,  BPH (prostate),  Cancer - Breast,  Cancer - Colon,  Cancer - Prostate,  Cardiovascular,  Chronic Obstructive Pulmonary Disease,  Cognitive Decline,  Colds,  COVID,  Depression,  Diabetes,  Endometriosis,  Falls,  Fibromyalgia,  Hashimoto's Thyroiditis,  Hay Fever,  Heart Failure,  Hives,  Hypertension – Pulmonary,  Immune System,  Infant,  Inflammatory Bowel Syndrome,  Influenza,  Kidney Disease,  Knee-Pain,  Lupus,  Migraine,  Multiple Sclerosis,  Muscles - women, Obesity,  Pain - Chronic,  Pain - Growing,  PMS,  Preeclampsia,  Premature Birth,  Respiratory Tract Infection,  Schizophrenia,  Sleep-Poor,  Sleep Apnea,  Smoking,  Sports Performance,  Stroke,  Surgery,  Tonsilitis,  Tuberculosis,  Ulcerative Colitis,  Ulcers – Venous,  Urinary Tract Infection   click here for proof

Note: Magnesium and Omega-3 work synergistically with Vitamin D - such as reducing depression

14 studies in both categories Depression and Magnesium

This list is automatically updated

29 studies in both categories Depression and Omega-3

This list is automatically updated

Many otther health problems are now fought by the combo - unware of any depression studies using the combo

Many of the high-dose vitamin D therapies include Magnesium and Omega-

35 studies in both categories Magnesium and Omega-3

This list is automatically updated

Created by admin. Last Modification: Saturday November 12, 2022 16:10:53 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
18793 Depression RCT_CompressPdf.pdf admin 12 Nov, 2022 232.86 Kb 85